Harnessing radiotherapy-induced NK-cell activity by combining DNA damage–response inhibition and immune checkpoint blockade

BACKGROUND: Despite therapeutic gains from immune checkpoint inhibitors (ICI) in many tumor types, new strategies are needed to extend treatment benefits, especially in patients failing to mount effective antitumor T-cell responses. Radiation and drug therapies can profoundly affect the tumor immune...

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Detalles Bibliográficos
Autores principales: Patin, Emmanuel C, Dillon, Magnus T, Nenclares, Pablo, Grove, Lorna, Soliman, Heba, Leslie, Isla, Northcote, Davina, Bozhanova, Galabina, Crespo-Rodriguez, Eva, Baldock, Holly, Whittock, Harriet, Baker, Gabriella, Kyula, Joan, Guevara, Jeane, Melcher, Alan A, Harper, James, Ghadially, Hormas, Smith, Simon, Pedersen, Malin, McLaughlin, Martin, Harrington, Kevin J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938703/
https://www.ncbi.nlm.nih.gov/pubmed/35314434
http://dx.doi.org/10.1136/jitc-2021-004306

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