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Basal Ganglia Iron Content Increases with Glioma Severity Using Quantitative Susceptibility Mapping: A Potential Biomarker of Tumor Severity

Background and Purpose: Gliomas have been found to alter iron metabolism and transport in ways that result in an expansion of their intracellular iron compartments to support aggressive tumor growth. This study used deep neural network trained quantitative susceptibility mapping to assess basal gang...

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Autores principales: Reith, Thomas P., Prah, Melissa A., Choi, Eun-Jung, Lee, Jongho, Wujek, Robert, Al-Gizawiy, Mona, Chitambar, Christopher R., Connelly, Jennifer M., Schmainda, Kathleen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938779/
https://www.ncbi.nlm.nih.gov/pubmed/35314642
http://dx.doi.org/10.3390/tomography8020065
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author Reith, Thomas P.
Prah, Melissa A.
Choi, Eun-Jung
Lee, Jongho
Wujek, Robert
Al-Gizawiy, Mona
Chitambar, Christopher R.
Connelly, Jennifer M.
Schmainda, Kathleen M.
author_facet Reith, Thomas P.
Prah, Melissa A.
Choi, Eun-Jung
Lee, Jongho
Wujek, Robert
Al-Gizawiy, Mona
Chitambar, Christopher R.
Connelly, Jennifer M.
Schmainda, Kathleen M.
author_sort Reith, Thomas P.
collection PubMed
description Background and Purpose: Gliomas have been found to alter iron metabolism and transport in ways that result in an expansion of their intracellular iron compartments to support aggressive tumor growth. This study used deep neural network trained quantitative susceptibility mapping to assess basal ganglia iron concentrations in glioma patients. Materials and Methods: Ninety-two patients with brain lesions were initially enrolled in this study and fifty-nine met the inclusion criteria. Susceptibility-weighted images were collected at 3.0 T and used to construct quantitative susceptibility maps via a deep neural network-based method. The regions of interest were manually drawn within basal ganglia structures and the mean voxel intensities were extracted and averaged across multiple slices. One-way ANCOVA tests were conducted to compare the susceptibility values of groups of patients based on tumor grade while controlling for age, sex, and tumor type. Results: The mean basal ganglia susceptibility for patients with grade IV tumors was higher than that for patients with grade II tumors (p = 0.00153) and was also higher for patients with grade III tumors compared to patients with grade II tumors (p = 0.020), after controlling for age, sex, and tumor type. Patient age influenced susceptibility values (p = 0.00356), while sex (p = 0.69) and tumor type (p = 0.11) did not. Conclusions: The basal ganglia iron content increased with glioma severity. Basal ganglia iron levels may thus be a useful biomarker in glioma prognosis and treatment, especially with regard to iron-based cancer therapies.
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spelling pubmed-89387792022-03-23 Basal Ganglia Iron Content Increases with Glioma Severity Using Quantitative Susceptibility Mapping: A Potential Biomarker of Tumor Severity Reith, Thomas P. Prah, Melissa A. Choi, Eun-Jung Lee, Jongho Wujek, Robert Al-Gizawiy, Mona Chitambar, Christopher R. Connelly, Jennifer M. Schmainda, Kathleen M. Tomography Article Background and Purpose: Gliomas have been found to alter iron metabolism and transport in ways that result in an expansion of their intracellular iron compartments to support aggressive tumor growth. This study used deep neural network trained quantitative susceptibility mapping to assess basal ganglia iron concentrations in glioma patients. Materials and Methods: Ninety-two patients with brain lesions were initially enrolled in this study and fifty-nine met the inclusion criteria. Susceptibility-weighted images were collected at 3.0 T and used to construct quantitative susceptibility maps via a deep neural network-based method. The regions of interest were manually drawn within basal ganglia structures and the mean voxel intensities were extracted and averaged across multiple slices. One-way ANCOVA tests were conducted to compare the susceptibility values of groups of patients based on tumor grade while controlling for age, sex, and tumor type. Results: The mean basal ganglia susceptibility for patients with grade IV tumors was higher than that for patients with grade II tumors (p = 0.00153) and was also higher for patients with grade III tumors compared to patients with grade II tumors (p = 0.020), after controlling for age, sex, and tumor type. Patient age influenced susceptibility values (p = 0.00356), while sex (p = 0.69) and tumor type (p = 0.11) did not. Conclusions: The basal ganglia iron content increased with glioma severity. Basal ganglia iron levels may thus be a useful biomarker in glioma prognosis and treatment, especially with regard to iron-based cancer therapies. MDPI 2022-03-15 /pmc/articles/PMC8938779/ /pubmed/35314642 http://dx.doi.org/10.3390/tomography8020065 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Reith, Thomas P.
Prah, Melissa A.
Choi, Eun-Jung
Lee, Jongho
Wujek, Robert
Al-Gizawiy, Mona
Chitambar, Christopher R.
Connelly, Jennifer M.
Schmainda, Kathleen M.
Basal Ganglia Iron Content Increases with Glioma Severity Using Quantitative Susceptibility Mapping: A Potential Biomarker of Tumor Severity
title Basal Ganglia Iron Content Increases with Glioma Severity Using Quantitative Susceptibility Mapping: A Potential Biomarker of Tumor Severity
title_full Basal Ganglia Iron Content Increases with Glioma Severity Using Quantitative Susceptibility Mapping: A Potential Biomarker of Tumor Severity
title_fullStr Basal Ganglia Iron Content Increases with Glioma Severity Using Quantitative Susceptibility Mapping: A Potential Biomarker of Tumor Severity
title_full_unstemmed Basal Ganglia Iron Content Increases with Glioma Severity Using Quantitative Susceptibility Mapping: A Potential Biomarker of Tumor Severity
title_short Basal Ganglia Iron Content Increases with Glioma Severity Using Quantitative Susceptibility Mapping: A Potential Biomarker of Tumor Severity
title_sort basal ganglia iron content increases with glioma severity using quantitative susceptibility mapping: a potential biomarker of tumor severity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938779/
https://www.ncbi.nlm.nih.gov/pubmed/35314642
http://dx.doi.org/10.3390/tomography8020065
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