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Nuclear Expression of p-STAT3 Is Associated with Poor Prognosis in ER(−) Breast Cancer
The activation of signal transducer and activator of transcription 3 (STAT3) has been reported in several types of cancer, where it acts as an oncogene. However, in breast cancer, the clinical role of STAT3 remains unclear. In the present study, the association between phosphorylated-STAT3 (p-STAT3)...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938801/ https://www.ncbi.nlm.nih.gov/pubmed/35314590 http://dx.doi.org/10.3390/clinpract12020020 |
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author | Nakagawa, Tsuyoshi Oda, Goshi Kawachi, Hiroshi Ishikawa, Toshiaki Okamoto, Kentaro Uetake, Hiroyuki |
author_facet | Nakagawa, Tsuyoshi Oda, Goshi Kawachi, Hiroshi Ishikawa, Toshiaki Okamoto, Kentaro Uetake, Hiroyuki |
author_sort | Nakagawa, Tsuyoshi |
collection | PubMed |
description | The activation of signal transducer and activator of transcription 3 (STAT3) has been reported in several types of cancer, where it acts as an oncogene. However, in breast cancer, the clinical role of STAT3 remains unclear. In the present study, the association between phosphorylated-STAT3 (p-STAT3) expression and clinicopathological/biological factors was examined in each subtype. p-STAT3 expression was examined in 135 cases of breast cancer by immunohistochemistry. p-STAT3 expression was not associated with clinicopathological/biological factors and prognosis in a complete cohort of breast cancer cases. However, in patients with estrogen receptor-negative (ER(−)) breast cancer and triple-negative breast cancer (TNBC), multivariate analysis showed that higher p-STAT3 expression was significantly associated with a short relapse-free survival (p = 0.029, HR 5.37, 95%CI 1.19–24.29). TNBC patients with p-STAT3 overexpression were found to have a poor prognosis (p = 0.029, HR 5.37, 95%CI 1.19–24.29). On the other hand, in ER(+) breast cancer, p-STAT3 overexpression was associated with a favorable prognosis (p = 0.034, HR 9.48, 95%CI 1.18–76.21). The present results suggested that STAT3 expression may play a different role in ER(−) and ER(+) breast cancer. In the future, the pharmacological inhibition of STAT3 expression may serve as an effective therapeutic strategy for ER(−) breast cancer, particularly TNBC. |
format | Online Article Text |
id | pubmed-8938801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89388012022-03-23 Nuclear Expression of p-STAT3 Is Associated with Poor Prognosis in ER(−) Breast Cancer Nakagawa, Tsuyoshi Oda, Goshi Kawachi, Hiroshi Ishikawa, Toshiaki Okamoto, Kentaro Uetake, Hiroyuki Clin Pract Article The activation of signal transducer and activator of transcription 3 (STAT3) has been reported in several types of cancer, where it acts as an oncogene. However, in breast cancer, the clinical role of STAT3 remains unclear. In the present study, the association between phosphorylated-STAT3 (p-STAT3) expression and clinicopathological/biological factors was examined in each subtype. p-STAT3 expression was examined in 135 cases of breast cancer by immunohistochemistry. p-STAT3 expression was not associated with clinicopathological/biological factors and prognosis in a complete cohort of breast cancer cases. However, in patients with estrogen receptor-negative (ER(−)) breast cancer and triple-negative breast cancer (TNBC), multivariate analysis showed that higher p-STAT3 expression was significantly associated with a short relapse-free survival (p = 0.029, HR 5.37, 95%CI 1.19–24.29). TNBC patients with p-STAT3 overexpression were found to have a poor prognosis (p = 0.029, HR 5.37, 95%CI 1.19–24.29). On the other hand, in ER(+) breast cancer, p-STAT3 overexpression was associated with a favorable prognosis (p = 0.034, HR 9.48, 95%CI 1.18–76.21). The present results suggested that STAT3 expression may play a different role in ER(−) and ER(+) breast cancer. In the future, the pharmacological inhibition of STAT3 expression may serve as an effective therapeutic strategy for ER(−) breast cancer, particularly TNBC. MDPI 2022-02-25 /pmc/articles/PMC8938801/ /pubmed/35314590 http://dx.doi.org/10.3390/clinpract12020020 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nakagawa, Tsuyoshi Oda, Goshi Kawachi, Hiroshi Ishikawa, Toshiaki Okamoto, Kentaro Uetake, Hiroyuki Nuclear Expression of p-STAT3 Is Associated with Poor Prognosis in ER(−) Breast Cancer |
title | Nuclear Expression of p-STAT3 Is Associated with Poor Prognosis in ER(−) Breast Cancer |
title_full | Nuclear Expression of p-STAT3 Is Associated with Poor Prognosis in ER(−) Breast Cancer |
title_fullStr | Nuclear Expression of p-STAT3 Is Associated with Poor Prognosis in ER(−) Breast Cancer |
title_full_unstemmed | Nuclear Expression of p-STAT3 Is Associated with Poor Prognosis in ER(−) Breast Cancer |
title_short | Nuclear Expression of p-STAT3 Is Associated with Poor Prognosis in ER(−) Breast Cancer |
title_sort | nuclear expression of p-stat3 is associated with poor prognosis in er(−) breast cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938801/ https://www.ncbi.nlm.nih.gov/pubmed/35314590 http://dx.doi.org/10.3390/clinpract12020020 |
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