Cargando…

First-in-human phase I clinical trial of a TLR4-binding DNA aptamer, ApTOLL: Safety and pharmacokinetics in healthy volunteers

ApTOLL is an aptamer that antagonizes Toll-like receptor 4 and improves functional outcomes in models of ischemic stroke and myocardial infarction. The aim of this study was to characterize the safety and pharmacokinetics of ApTOLL in healthy volunteers. A first-in-human dose-ascending, randomized,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hernández-Jiménez, Macarena, Martín-Vílchez, Samuel, Ochoa, Dolores, Mejía-Abril, Gina, Román, Manuel, Camargo-Mamani, Paola, Luquero-Bueno, Sergio, Jilma, Bernd, Moro, María A., Fernández, Gerónimo, Piñeiro, David, Ribó, Marc, González, Víctor M., Lizasoain, Ignacio, Abad-Santos, Francisco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938885/ https://www.ncbi.nlm.nih.gov/pubmed/35402075 http://dx.doi.org/10.1016/j.omtn.2022.03.005

Ejemplares similares

APRIL: A double-blind, placebo-controlled, randomized, Phase Ib/IIa clinical study of ApTOLL for the treatment of acute ischemic stroke
por: Hernández-Jiménez, Macarena, et al.
Publicado: (2023)

Targeting TLR4 with ApTOLL Improves Heart Function in Response to Coronary Ischemia Reperfusion in Pigs Undergoing Acute Myocardial Infarction
por: Ramirez-Carracedo, Rafael, et al.
Publicado: (2020)

Identification of Transporter Polymorphisms Influencing Metformin Pharmacokinetics in Healthy Volunteers
por: Saiz-Rodríguez, Miriam, et al.
Publicado: (2023)

Bioavailability of Oniria(®), a Melatonin Prolonged-Release Formulation, Versus Immediate-Release Melatonin in Healthy Volunteers
por: Román Martinez, Manuel, et al.
Publicado: (2022)

Impact of Sex and Genetic Variation in Relevant Pharmacogenes on the Pharmacokinetics and Safety of Valsartan, Olmesartan and Hydrochlorothiazide
por: Soria-Chacartegui, Paula, et al.
Publicado: (2023)

Polymorphism of Drug Transporters, Rather Than Metabolizing Enzymes, Conditions the Pharmacokinetics of Rasagiline
por: Zubiaur, Pablo, et al.
Publicado: (2022)

Use of Aptamers as Diagnostics Tools and Antiviral Agents for Human Viruses
por: González, Víctor M., et al.
Publicado: (2016)

Test repositioning for functional assessment of neurological outcome after experimental stroke in mice
por: Hernández-Jiménez, Macarena, et al.
Publicado: (2017)

Potent and rapid reversal of the von Willebrand factor inhibitor aptamer BT200
por: Zhu, Shuhao, et al.
Publicado: (2020)

Surface cooling for induction of mild hypothermia in conscious healthy volunteers - a feasibility trial
por: Testori, Christoph, et al.
Publicado: (2011)

Pharmacokinetics and Safety of a Bilastine Once-Daily, Preservative-Free, Ophthalmic Formulation
por: Ochoa, Dolores, et al.
Publicado: (2021)

The von Willebrand factor–binding aptamer rondaptivon pegol as a treatment for severe and nonsevere hemophilia A
por: Ay, Cihan, et al.
Publicado: (2023)

Aging increases microglial proliferation, delays cell migration, and decreases cortical neurogenesis after focal cerebral ischemia
por: Moraga, Ana, et al.
Publicado: (2015)

The VWF binding aptamer rondoraptivon pegol increases platelet counts and VWF/FVIII in type 2B von Willebrand disease
por: Ay, Cihan, et al.
Publicado: (2022)

The development and characterization of a long acting anti‐thrombotic von Willebrand factor (VWF) aptamer
por: Zhu, Shuhao, et al.
Publicado: (2020)

SLCO1B1 Phenotype and CYP3A5 Polymorphism Significantly Affect Atorvastatin Bioavailability
por: Zubiaur, Pablo, et al.
Publicado: (2021)

Effects of Cytochrome P450 and Transporter Polymorphisms on the Bioavailability and Safety of Dutasteride and Tamsulosin
por: Villapalos-García, Gonzalo, et al.
Publicado: (2021)

Pharmacokinetic Modeling of Morphine’s Effect on Plasma Concentrations of Ticagrelor and Its Metabolite in Healthy Volunteers
por: Buszko, Katarzyna, et al.
Publicado: (2021)

An optimized MNK1b aptamer, apMNKQ2, and its potential use as a therapeutic agent in breast cancer
por: Pinto-Díez, C., et al.
Publicado: (2022)

DNA Aptamers Selectively Target Leishmania infantum H2A Protein
por: Martín, M. Elena, et al.
Publicado: (2013)

Single, very low rituximab doses in healthy volunteers - a pilot and a randomized trial: implications for dosing and biosimilarity testing
por: Schoergenhofer, Christian, et al.
Publicado: (2018)

The aptamer BT200 blocks von Willebrand factor and platelet function in blood of stroke patients
por: Kovacevic, Katarina D., et al.
Publicado: (2021)

Amphetamine manipulates monoamine oxidase-A level and behavior using theranostic aptamers of transcription factors AP-1/NF-kB
por: Liu, Christina H., et al.
Publicado: (2016)

Morphine interaction with prasugrel: a double-blind, cross-over trial in healthy volunteers
por: Hobl, Eva-Luise, et al.
Publicado: (2015)

Advanced pharmacodynamics of cangrelor in healthy volunteers: a dose-finding, open-label, pilot trial
por: Gelbenegger, Georg, et al.
Publicado: (2022)

Granulocyte colony-stimulating factor (G-CSF) increases histone-complexed DNA plasma levels in healthy volunteers
por: Schoergenhofer, Christian, et al.
Publicado: (2016)

Cannabinoids: Well-Suited Candidates for the Treatment of Perinatal Brain Injury
por: Fernández-López, David, et al.
Publicado: (2013)

Toll-like Receptors as Pro-Thrombotic Drivers in Viral Infections: A Narrative Review
por: Panzer, Benjamin, et al.
Publicado: (2023)

The von Willebrand factor A-1 domain binding aptamer BT200 elevates plasma levels of von Willebrand factor and factor VIII: a first-in-human trial
por: Kovacevic, Katarina D., et al.
Publicado: (2021)

Impact of polymorphisms in CYP and UGT enzymes and ABC and SLCO1B1 transporters on the pharmacokinetics and safety of desvenlafaxine
por: Calleja, Sofía, et al.
Publicado: (2023)

Defibrotide enhances fibrinolysis in human endotoxemia – a randomized, double blind, crossover trial in healthy volunteers
por: Schoergenhofer, Christian, et al.
Publicado: (2019)

A Single and Multiple Ascending Dose Study of Toll‐Like Receptor 7 Agonist (RO7020531) in Chinese Healthy Volunteers
por: Luk, Andrea, et al.
Publicado: (2020)

A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer
por: Rammensee, Hans-Georg, et al.
Publicado: (2019)

Metrología y Ensayos
por: Moro Piñeiro, María
Publicado: (2018)

Fundamentos de metrología dimensional /
por: Moro Piñeiro, María‏
Publicado: (2017)

Non-invasive monitoring of intracranial pressure changes: healthy volunteers study
por: Roldan, Maria, et al.
Publicado: (2023)

MiniAp‐4: A Venom‐Inspired Peptidomimetic for Brain Delivery
por: Oller‐Salvia, Benjamí, et al.
Publicado: (2015)

Estimating Traffic Disruption Patterns with Volunteered Geographic Information
por: Camargo, Chico Q., et al.
Publicado: (2020)

The aptamer BT200 effectively inhibits von Willebrand factor (VWF) dependent platelet function after stimulated VWF release by desmopressin or endotoxin
por: Kovacevic, Katarina D., et al.
Publicado: (2020)

Aptamer Bioinformatics
por: Kinghorn, Andrew B., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_50utraejtbqrt6eh9pi85vs4e9