Planar Chiral 1,3-Disubstituted Ferrocenyl Phosphine Gold(I) Catalysts

[Image: see text] Planar chiral monodentate 1,3-disubstituted ferrocene phosphines inspired on JohnPhos-type ligands have been synthesized and applied to the enantioselective gold(I) catalyzed [4 + 2] cycloaddition of 1,6-arylenynes. Computational studies rationalized the working mode of the catalys...

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Detalles Bibliográficos
Autores principales: Caniparoli, Ulysse, Escofet, Imma, Echavarren, Antonio M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938926/
https://www.ncbi.nlm.nih.gov/pubmed/35356706
http://dx.doi.org/10.1021/acscatal.1c05827
Descripción
Sumario:[Image: see text] Planar chiral monodentate 1,3-disubstituted ferrocene phosphines inspired on JohnPhos-type ligands have been synthesized and applied to the enantioselective gold(I) catalyzed [4 + 2] cycloaddition of 1,6-arylenynes. Computational studies rationalized the working mode of the catalyst on the folding of the substrate in the chiral environment of the ligand involving attractive noncovalent interactions.

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