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SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas

Inherited pathogenic succinate dehydrogenase (SDHx) gene mutations cause the hereditary pheochromocytoma and paraganglioma tumor syndrome. Syndromic tumors exhibit elevated succinate, an oncometabolite that is proposed to drive tumorigenesis via DNA and histone hypermethylation, mitochondrial expans...

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Detalles Bibliográficos
Autores principales:	Armstrong, Neali, Storey, Claire M., Noll, Sarah E., Margulis, Katherine, Soe, Myat Han, Xu, Haixia, Yeh, Benjamin, Fishbein, Lauren, Kebebew, Electron, Howitt, Brooke E., Zare, Richard N., Sage, Julien, Annes, Justin P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8939053/ https://www.ncbi.nlm.nih.gov/pubmed/35235785 http://dx.doi.org/10.1016/j.celrep.2022.110453

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