Antibody-drug conjugates targeting CD248 inhibits liver fibrosis through specific killing on myofibroblasts

BACKGROUND: Chronic liver injury induces pathological repair, resulting in fibrosis, during which hepatic stellate cells (HSCs) are activated and transform into myofibroblasts. CD248 is mainly expressed on myofibroblasts and was considered as a promising target to treat fibrosis. The primary aim of...

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Detalles Bibliográficos
Autores principales: Liu, Shaojie, Han, Donghui, Xu, Chao, Yang, Fa, Li, Yu, Zhang, Keying, Zhao, Xiaolong, Zhang, Jiayu, Lu, Tong, Lu, Shiqi, Shi, Changhong, Zhang, Rui, Yang, An-Gang, Zhao, Aizhi, Qin, Weijun, Yang, Bo, Wen, Weihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8939076/
https://www.ncbi.nlm.nih.gov/pubmed/35317721
http://dx.doi.org/10.1186/s10020-022-00460-1

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