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Roles of sirtuin family members in chronic obstructive pulmonary disease

The globally increasing annual incidence of chronic obstructive pulmonary disease (COPD), a common chronic disease, poses a serious risk to public health. Although the exact mechanism underlying the pathogenesis of COPD remains unclear, a large number of studies have shown that its pathophysiology a...

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Autores principales: Zhang, Xi-Yue, Li, Wei, Zhang, Jin-Rong, Li, Chun-Yan, Zhang, Jie, Lv, Xue-Jiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8939123/
https://www.ncbi.nlm.nih.gov/pubmed/35313881
http://dx.doi.org/10.1186/s12931-022-01986-y
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author Zhang, Xi-Yue
Li, Wei
Zhang, Jin-Rong
Li, Chun-Yan
Zhang, Jie
Lv, Xue-Jiao
author_facet Zhang, Xi-Yue
Li, Wei
Zhang, Jin-Rong
Li, Chun-Yan
Zhang, Jie
Lv, Xue-Jiao
author_sort Zhang, Xi-Yue
collection PubMed
description The globally increasing annual incidence of chronic obstructive pulmonary disease (COPD), a common chronic disease, poses a serious risk to public health. Although the exact mechanism underlying the pathogenesis of COPD remains unclear, a large number of studies have shown that its pathophysiology and disease course are closely related to oxidative stress, inflammation, apoptosis, autophagy, and aging. The key players involved in COPD include the sirtuin family of NAD-dependent deacetylases that comprise seven members (SIRT1–7) in mammals. Sirtuins play an important role in metabolic diseases, cell cycle control, proliferation, apoptosis, and senescence. Owing to differences in subcellular localization, sirtuins exhibit anisotropy. In this narrative review, we discuss the roles and molecular pathways of each member of the sirtuin family involved in COPD to provide novel insights into the prevention and treatment of COPD and how sirtuins may serve as adjuvants for COPD treatment.
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spelling pubmed-89391232022-03-23 Roles of sirtuin family members in chronic obstructive pulmonary disease Zhang, Xi-Yue Li, Wei Zhang, Jin-Rong Li, Chun-Yan Zhang, Jie Lv, Xue-Jiao Respir Res Review The globally increasing annual incidence of chronic obstructive pulmonary disease (COPD), a common chronic disease, poses a serious risk to public health. Although the exact mechanism underlying the pathogenesis of COPD remains unclear, a large number of studies have shown that its pathophysiology and disease course are closely related to oxidative stress, inflammation, apoptosis, autophagy, and aging. The key players involved in COPD include the sirtuin family of NAD-dependent deacetylases that comprise seven members (SIRT1–7) in mammals. Sirtuins play an important role in metabolic diseases, cell cycle control, proliferation, apoptosis, and senescence. Owing to differences in subcellular localization, sirtuins exhibit anisotropy. In this narrative review, we discuss the roles and molecular pathways of each member of the sirtuin family involved in COPD to provide novel insights into the prevention and treatment of COPD and how sirtuins may serve as adjuvants for COPD treatment. BioMed Central 2022-03-21 2022 /pmc/articles/PMC8939123/ /pubmed/35313881 http://dx.doi.org/10.1186/s12931-022-01986-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Xi-Yue
Li, Wei
Zhang, Jin-Rong
Li, Chun-Yan
Zhang, Jie
Lv, Xue-Jiao
Roles of sirtuin family members in chronic obstructive pulmonary disease
title Roles of sirtuin family members in chronic obstructive pulmonary disease
title_full Roles of sirtuin family members in chronic obstructive pulmonary disease
title_fullStr Roles of sirtuin family members in chronic obstructive pulmonary disease
title_full_unstemmed Roles of sirtuin family members in chronic obstructive pulmonary disease
title_short Roles of sirtuin family members in chronic obstructive pulmonary disease
title_sort roles of sirtuin family members in chronic obstructive pulmonary disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8939123/
https://www.ncbi.nlm.nih.gov/pubmed/35313881
http://dx.doi.org/10.1186/s12931-022-01986-y
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