SARS-CoV-2 NSP13 helicase suppresses interferon signaling by perturbing JAK1 phosphorylation of STAT1

BACKGROUND: SARS-CoV-2 is the causative agent of COVID-19. Overproduction and release of proinflammatory cytokines are the underlying cause of severe COVID-19. Treatment of this condition with JAK inhibitors is a double-edged sword, which might result in the suppression of proinflammatory cytokine s...

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Detalles Bibliográficos
Autores principales: Fung, Sin-Yee, Siu, Kam-Leung, Lin, Huayue, Chan, Ching-Ping, Yeung, Man Lung, Jin, Dong-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8939493/
https://www.ncbi.nlm.nih.gov/pubmed/35317858
http://dx.doi.org/10.1186/s13578-022-00770-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8939493/
https://www.ncbi.nlm.nih.gov/pubmed/35317858
http://dx.doi.org/10.1186/s13578-022-00770-1

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