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SARS-CoV-2 NSP13 helicase suppresses interferon signaling by perturbing JAK1 phosphorylation of STAT1

BACKGROUND: SARS-CoV-2 is the causative agent of COVID-19. Overproduction and release of proinflammatory cytokines are the underlying cause of severe COVID-19. Treatment of this condition with JAK inhibitors is a double-edged sword, which might result in the suppression of proinflammatory cytokine s...

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Detalles Bibliográficos
Autores principales:	Fung, Sin-Yee, Siu, Kam-Leung, Lin, Huayue, Chan, Ching-Ping, Yeung, Man Lung, Jin, Dong-Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8939493/ https://www.ncbi.nlm.nih.gov/pubmed/35317858 http://dx.doi.org/10.1186/s13578-022-00770-1

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