Cargando…

A Thromboxane A(2) Receptor-Driven COX-2–Dependent Feedback Loop That Affects Endothelial Homeostasis and Angiogenesis

TP (thromboxane A(2) receptor) plays an eminent role in the pathophysiology of endothelial dysfunction and cardiovascular disease. Moreover, its expression is reported to increase in the intimal layer of blood vessels of cardiovascular high-risk individuals. Yet it is unknown, whether TP upregulatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eckenstaler, Robert, Ripperger, Anne, Hauke, Michael, Petermann, Markus, Hemkemeyer, Sandra A., Schwedhelm, Edzard, Ergün, Süleyman, Frye, Maike, Werz, Oliver, Koeberle, Andreas, Braun, Heike, Benndorf, Ralf A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2022
Materias:	Basic Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8939709/ https://www.ncbi.nlm.nih.gov/pubmed/35236104 http://dx.doi.org/10.1161/ATVBAHA.121.317380

Ejemplares similares

Active RhoA Exerts an Inhibitory Effect on the Homeostasis and Angiogenic Capacity of Human Endothelial Cells
por: Hauke, Michael, et al.
Publicado: (2022)

Impact of DICER1 and DROSHA on the Angiogenic Capacity of Human Endothelial Cells
por: Braun, Heike, et al.
Publicado: (2021)

3D structure of the transporter ABCG2—What's new?
por: Eckenstaler, Robert, et al.
Publicado: (2020)

The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout—An Update
por: Eckenstaler, Robert, et al.
Publicado: (2021)

Targeting the COX1/2-Driven thromboxane A2 pathway suppresses Barrett's esophagus and esophageal adenocarcinoma development
por: Zhang, Tianshun, et al.
Publicado: (2019)

Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A(2)
por: Lucotti, Serena, et al.
Publicado: (2019)

A Combined Acceptor Photobleaching and Donor Fluorescence Lifetime Imaging Microscopy Approach to Analyze Multi-Protein Interactions in Living Cells
por: Eckenstaler, Robert, et al.
Publicado: (2021)

Daidzein Inhibits Human Platelet Activation by Downregulating Thromboxane A(2) Production and Granule Release, Regardless of COX-1 Activity
por: Hong, Hyun-Jin, et al.
Publicado: (2023)

Expression of thromboxane synthase, TBXAS1 and the thromboxane A2 receptor, TBXA2R, in human breast cancer
por: Watkins, Gareth, et al.
Publicado: (2005)

The function and mechanism of COX-2 in angiogenesis of gastric cancer cells
por: Yao, Liping, et al.
Publicado: (2011)

Thromboxane Modulates Endothelial Permeability
por: Klausner, J. M., et al.
Publicado: (1994)

Stability of thromboxane in blood samples
por: Helgadóttir, Helga, et al.
Publicado: (2019)

An antiangiogenic neurokinin-B/thromboxane A2 regulatory axis
por: Pal, Saumen, et al.
Publicado: (2006)

Inhibiting breast cancer by targeting the thromboxane A(2) pathway
por: Li, Haitao, et al.
Publicado: (2017)

The Role of 20-HETE, COX, Thromboxane Receptors, and Blood Plasma Antioxidant Status in Vascular Relaxation of Copper-Nanoparticle-Fed WKY Rats
por: Majewski, Michał, et al.
Publicado: (2021)

Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-κB-driven inflammation through redox-active mechanisms
por: Koeberle, Solveigh C., et al.
Publicado: (2019)

Urinary 11‐Dehydro‐Thromboxane B(2) as a Predictor of Acute Myocardial Infarction Outcomes: Results of Leukotrienes and Thromboxane In Myocardial Infarction (LTIMI) Study
por: Szczeklik, Wojciech, et al.
Publicado: (2016)

Measurement of Thromboxane Biosynthesis in Health and Disease
por: Patrono, Carlo, et al.
Publicado: (2019)

Synthesis, Stability, and Biological Studies of Fluorinated Analogues of Thromboxane A(2)
por: Jing, Changcheng, et al.
Publicado: (2020)

Pharmacogenetic Aspects of the Interaction of AT1 Receptor Antagonists With ATP-Binding Cassette Transporter ABCG2
por: Ripperger, Anne, et al.
Publicado: (2018)

Fibroblasts mediate the angiogenesis of pheochromocytoma by increasing COX4I2 expression
por: Mao, Yongxin, et al.
Publicado: (2022)

Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria
por: Mick, David U., et al.
Publicado: (2010)

Bone marrow-independent adventitial macrophage progenitor cells contribute to angiogenesis
por: Kleefeldt, Florian, et al.
Publicado: (2022)

Prostaglandin cyclooxygenase products but not thromboxane A(2) are involved in the pathogenesis of ewthromelalgia in thrombocythaemia
por: Michiels, J. J., et al.
Publicado: (1993)

Contribution of Thromboxane A(2) in Rat Common Carotid Artery Response to Serotonin
por: Radenković, Miroslav, et al.
Publicado: (2010)

Inverse Agonism of SQ 29,548 and Ramatroban on Thromboxane A2 Receptor
por: Chakraborty, Raja, et al.
Publicado: (2014)

Investigation of a Thromboxane A(2) Receptor–Based Vaccine for Managing Thrombogenesis
por: Alshbool, Fatima Z., et al.
Publicado: (2018)

The Role and Regulation of Thromboxane A(2) Signaling in Cancer-Trojan Horses and Misdirection
por: Ashton, Anthony W., et al.
Publicado: (2022)

Effects of Fatty Acid Metabolites on Adipocytes Britening: Role of Thromboxane A2
por: Colson, Cécilia, et al.
Publicado: (2023)

Foetal vascular responses to thromboxane receptor blockade
por: Meyer, B. A., et al.
Publicado: (1992)

Prostacyclin and thromboxane in benign and malignant breast tumours.
por: Laekeman, G. M., et al.
Publicado: (1986)

ADP and Thromboxane Inhibitors Both Reduce Global Contraction of Clot Length, While Thromboxane Inhibition Attenuates Internal Aggregate Contraction
por: Trigani, Kevin T., et al.
Publicado: (2022)

Aiphanol, a native compound, suppresses angiogenesis via dual-targeting VEGFR2 and COX2
por: Chen, Shanmei, et al.
Publicado: (2021)

Differential modulation of microglia superoxide anion and thromboxane B(2 )generation by the marine manzamines
por: Mayer, Alejandro MS, et al.
Publicado: (2005)

Thromboxane A(2) is a key regulator of pathogenesis during Trypanosoma cruzi infection
por: Ashton, Anthony W., et al.
Publicado: (2007)

Regulation of the Tumor Suppressor FOXO3 by the Thromboxane-A(2) Receptors in Urothelial Cancer
por: Sobolesky, Philip M., et al.
Publicado: (2014)

Age-related increase of thromboxane B(2) and risk of cardiovascular disease in atrial fibrillation
por: Pastori, Daniele, et al.
Publicado: (2016)

Human Thromboxane A(2) Receptor Genetic Variants: In Silico, In Vitro and “In Platelet” Analysis
por: Gleim, Scott, et al.
Publicado: (2013)

Thromboxane A(2) exacerbates acute lung injury via promoting edema formation
por: Kobayashi, Koji, et al.
Publicado: (2016)

Influence of smoking and smoking cessation on levels of urinary 11-dehydro thromboxane B(2)
por: van der Plas, Angela, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_f55ai92tuq29j2ohpp86vfqcj8