Infiltration of inflammatory macrophages and neutrophils and widespread pyroptosis in lung drive influenza lethality in nonhuman primates

Severe influenza kills tens of thousands of individuals each year, yet the mechanisms driving lethality in humans are poorly understood. Here we used a unique translational model of lethal H5N1 influenza in cynomolgus macaques that utilizes inhalation of small-particle virus aerosols to define mecha...

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Detalles Bibliográficos
Autores principales: Corry, Jacqueline, Kettenburg, Gwenddolen, Upadhyay, Amit A., Wallace, Megan, Marti, Michelle M., Wonderlich, Elizabeth R., Bissel, Stephanie J., Goss, Kyndal, Sturgeon, Timothy J., Watkins, Simon C., Reed, Douglas S., Bosinger, Steven E., Barratt-Boyes, Simon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8939778/
https://www.ncbi.nlm.nih.gov/pubmed/35271686
http://dx.doi.org/10.1371/journal.ppat.1010395

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