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Fluctuations in quality of life and immune responses during intravenous immunoglobulin infusion cycles

Despite adequate infection prophylaxis, variation in self-reported quality of life (QOL) throughout the intravenous immunoglobulin (IVIG) infusion cycle is a widely reported but infrequently studied phenomenon. To better understand this phenomenon, subjects with humoral immunodeficiency receiving re...

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Autores principales: Abbott, Jordan K., Chan, Sanny K., MacBeth, Morgan, Crooks, James L., Hancock, Cathy, Knight, Vijaya, Gelfand, Erwin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8939786/
https://www.ncbi.nlm.nih.gov/pubmed/35316278
http://dx.doi.org/10.1371/journal.pone.0265852
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author Abbott, Jordan K.
Chan, Sanny K.
MacBeth, Morgan
Crooks, James L.
Hancock, Cathy
Knight, Vijaya
Gelfand, Erwin W.
author_facet Abbott, Jordan K.
Chan, Sanny K.
MacBeth, Morgan
Crooks, James L.
Hancock, Cathy
Knight, Vijaya
Gelfand, Erwin W.
author_sort Abbott, Jordan K.
collection PubMed
description Despite adequate infection prophylaxis, variation in self-reported quality of life (QOL) throughout the intravenous immunoglobulin (IVIG) infusion cycle is a widely reported but infrequently studied phenomenon. To better understand this phenomenon, subjects with humoral immunodeficiency receiving replacement doses of IVIG were studied over 3 infusion cycles. Questionnaire data from 6 time points spread over 3 IVIG infusions cycles (infusion day and 7 days after each infusion) were collected in conjunction with monitoring the blood for number of regulatory T-cells (Treg) and levels of 40 secreted analytes: primarily cytokines, chemokines, and growth factors. At day 7, self-reported well-being increased, and self-reported fatigue decreased, reflecting an overall improvement in QOL 7 days after infusion. Over the same period, percentage of Treg cells in the blood increased (p<0.01). Multiple inflammatory chemokine and cytokine levels increased in the blood by 1 hour after infusion (CCL4 (MIP-1b), CCL3 (MIP-1a), CCL2 (MCP-1), TNF-α, granzyme B, IL-10, IL-1RA, IL-8, IL-6, GM-CSF, and IFN- γ). The largest changes in analytes occurred in subjects initiated on IVIG during the study. A significant decrease in IL-25 (IL-17E) following infusion was seen in most intervals among subjects already receiving regular infusions prior to study entry. These findings reveal several short-term effects of IVIG given in replacement doses to patients with humoral immunodeficiency: QOL consistently improves in the first week of infusion, levels of a collection of monocyte-associated cytokines increase immediately after infusion whereas IL-25 levels decrease, and Treg levels increase. Moreover, patients that are new to IVIG experience more significant fluctuations in cytokine levels than those receiving it regularly.
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spelling pubmed-89397862022-03-23 Fluctuations in quality of life and immune responses during intravenous immunoglobulin infusion cycles Abbott, Jordan K. Chan, Sanny K. MacBeth, Morgan Crooks, James L. Hancock, Cathy Knight, Vijaya Gelfand, Erwin W. PLoS One Research Article Despite adequate infection prophylaxis, variation in self-reported quality of life (QOL) throughout the intravenous immunoglobulin (IVIG) infusion cycle is a widely reported but infrequently studied phenomenon. To better understand this phenomenon, subjects with humoral immunodeficiency receiving replacement doses of IVIG were studied over 3 infusion cycles. Questionnaire data from 6 time points spread over 3 IVIG infusions cycles (infusion day and 7 days after each infusion) were collected in conjunction with monitoring the blood for number of regulatory T-cells (Treg) and levels of 40 secreted analytes: primarily cytokines, chemokines, and growth factors. At day 7, self-reported well-being increased, and self-reported fatigue decreased, reflecting an overall improvement in QOL 7 days after infusion. Over the same period, percentage of Treg cells in the blood increased (p<0.01). Multiple inflammatory chemokine and cytokine levels increased in the blood by 1 hour after infusion (CCL4 (MIP-1b), CCL3 (MIP-1a), CCL2 (MCP-1), TNF-α, granzyme B, IL-10, IL-1RA, IL-8, IL-6, GM-CSF, and IFN- γ). The largest changes in analytes occurred in subjects initiated on IVIG during the study. A significant decrease in IL-25 (IL-17E) following infusion was seen in most intervals among subjects already receiving regular infusions prior to study entry. These findings reveal several short-term effects of IVIG given in replacement doses to patients with humoral immunodeficiency: QOL consistently improves in the first week of infusion, levels of a collection of monocyte-associated cytokines increase immediately after infusion whereas IL-25 levels decrease, and Treg levels increase. Moreover, patients that are new to IVIG experience more significant fluctuations in cytokine levels than those receiving it regularly. Public Library of Science 2022-03-22 /pmc/articles/PMC8939786/ /pubmed/35316278 http://dx.doi.org/10.1371/journal.pone.0265852 Text en © 2022 Abbott et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Abbott, Jordan K.
Chan, Sanny K.
MacBeth, Morgan
Crooks, James L.
Hancock, Cathy
Knight, Vijaya
Gelfand, Erwin W.
Fluctuations in quality of life and immune responses during intravenous immunoglobulin infusion cycles
title Fluctuations in quality of life and immune responses during intravenous immunoglobulin infusion cycles
title_full Fluctuations in quality of life and immune responses during intravenous immunoglobulin infusion cycles
title_fullStr Fluctuations in quality of life and immune responses during intravenous immunoglobulin infusion cycles
title_full_unstemmed Fluctuations in quality of life and immune responses during intravenous immunoglobulin infusion cycles
title_short Fluctuations in quality of life and immune responses during intravenous immunoglobulin infusion cycles
title_sort fluctuations in quality of life and immune responses during intravenous immunoglobulin infusion cycles
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8939786/
https://www.ncbi.nlm.nih.gov/pubmed/35316278
http://dx.doi.org/10.1371/journal.pone.0265852
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