The non-ELR CXC chemokine encoded by human cytomegalovirus UL146 genotype 5 contains a C-terminal β-hairpin and induces neutrophil migration as a selective CXCR2 agonist

Human cytomegalovirus (HCMV) is a major pathogen in immunocompromised patients. The UL146 gene exists as 14 diverse genotypes among clinical isolates, which encode 14 different CXC chemokines. One genotype (vCXCL1(GT1)) is a known agonist for CXCR1 and CXCR2, while two others (vCXCL1(GT5) and vCXCL1...

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Detalles Bibliográficos
Autores principales: Berg, Christian, Wedemeyer, Michael J., Melynis, Motiejus, Schlimgen, Roman R., Hansen, Lasse H., Våbenø, Jon, Peterson, Francis C., Volkman, Brian F., Rosenkilde, Mette M., Lüttichau, Hans R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8939814/
https://www.ncbi.nlm.nih.gov/pubmed/35271688
http://dx.doi.org/10.1371/journal.ppat.1010355

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