Specific HER2 Exon 20 Gly776 Deletion-Insertions in Non-Small Cell Lung Cancer: Structural Analysis and Sensitivity to HER2-Targeted Tyrosine Kinase Inhibitors

Background: HER2 exon 20 insertions remain a subset heterogeneous alterations in lung cancer, with currently unmet need for precision targeted therapy. G776delinsVC, a typical HER2 exon 20 deletion-insertion at codon Gly776, was reported to respond discrepantly to afatinib compared with the predomin...

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Detalles Bibliográficos
Autores principales: Yang, Guangjian, Xu, Haiyan, Hu, Jiaqi, Liu, Runze, Hu, Peizeng, Yang, Yaning, Li, Weihua, Hao, Xuezhi, Zhang, Shuyang, Xu, Fei, Ai, Xin, Li, Junling, Wang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940162/
https://www.ncbi.nlm.nih.gov/pubmed/35330827
http://dx.doi.org/10.3389/fphar.2022.806737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940162/
https://www.ncbi.nlm.nih.gov/pubmed/35330827
http://dx.doi.org/10.3389/fphar.2022.806737

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