Disulfiram Produces Potent Anxiolytic-Like Effects Without Benzodiazepine Anxiolytics-Related Adverse Effects in Mice

Disulfiram is an FDA approved drug for the treatment of alcoholism. The drug acts by inhibiting aldehyde dehydrogenase, an enzyme essential to alcohol metabolism. However, a recent study has demonstrated that disulfiram also potently inhibits the cytoplasmic protein FROUNT, a common regulator of che...

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Detalles Bibliográficos
Autores principales: Saitoh, Akiyoshi, Nagayama, Yoshifumi, Yamada, Daisuke, Makino, Kosho, Yoshioka, Toshinori, Yamanaka, Nanami, Nakatani, Momoka, Takahashi, Yoshino, Yamazaki, Mayuna, Shigemoto, Chihiro, Ohashi, Misaki, Okano, Kotaro, Omata, Tomoki, Toda, Etsuko, Sano, Yoshitake, Takahashi, Hideyo, Matsushima, Kouji, Terashima, Yuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940232/
https://www.ncbi.nlm.nih.gov/pubmed/35330835
http://dx.doi.org/10.3389/fphar.2022.826783

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