Cargando…
SARS-CoV-2 seroprevalence and determinants of infection in young adults: a population-based seroepidemiological study
OBJECTIVES: Most SARS-CoV-2 seroprevalence studies have focussed on adults and high-risk populations, and little is known about young adults. The objective of the present study was to provide evidence on the SARS-CoV-2 seroprevalence among young adults in Germany and to explore determinants associat...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society for Public Health. Published by Elsevier Ltd.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940565/ https://www.ncbi.nlm.nih.gov/pubmed/35490440 http://dx.doi.org/10.1016/j.puhe.2022.03.009 |
_version_ | 1784672952632999936 |
---|---|
author | Backhaus, I. Hermsen, D. Timm, J. Boege, F. Lübke, N. Degode, T. Göbels, K. Dragano, N. |
author_facet | Backhaus, I. Hermsen, D. Timm, J. Boege, F. Lübke, N. Degode, T. Göbels, K. Dragano, N. |
author_sort | Backhaus, I. |
collection | PubMed |
description | OBJECTIVES: Most SARS-CoV-2 seroprevalence studies have focussed on adults and high-risk populations, and little is known about young adults. The objective of the present study was to provide evidence on the SARS-CoV-2 seroprevalence among young adults in Germany and to explore determinants associated with seropositivity in general and, specifically, with previously undetected infections. STUDY DESIGN: This was a population-based SARS-CoV-2 seroprevalence study. METHODS: In November 2020, a population-based study on SARS-CoV-2 seroprevalence in young adults (aged 18–30 years) was conducted in a large German city. Serum samples were obtained to analyse the SARS-CoV-2 antibody status using the Elecsys Anti-SARS-CoV-2 immunoassay. Descriptive statistics and odds ratios (ORs) of seropositivity and of previously undetected infections in relation to different determinants were calculated. RESULTS: Among 2186 participants, SARS-CoV-2 antibodies were detected in 72 individuals, equalling a test performance-adjusted seroprevalence of 3.1% (95% confidence interval [CI]: 2.4–4.0). Based on reported COVID-19 cases to the public health authority, a moderate underascertainment rate of 1.7 was calculated. Seropositivity was higher among individuals who sought COVID-19-related information from social media (OR: 1.83, 95% CI: 1.2–3.1), and undetected COVID-19 infections were more prevalent among men and those not adhering to social distancing. CONCLUSIONS: The results show a substantial underascertainment of SARS-CoV-2 infections among young adults and indicate that seroprevalence is likely to be much higher than the reported COVID-19 prevalence based on confirmed COVID-19 cases in Germany. Preventive efforts should consider the heterogeneity of risk profiles among the young adult population. |
format | Online Article Text |
id | pubmed-8940565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society for Public Health. Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89405652022-03-23 SARS-CoV-2 seroprevalence and determinants of infection in young adults: a population-based seroepidemiological study Backhaus, I. Hermsen, D. Timm, J. Boege, F. Lübke, N. Degode, T. Göbels, K. Dragano, N. Public Health Original Research OBJECTIVES: Most SARS-CoV-2 seroprevalence studies have focussed on adults and high-risk populations, and little is known about young adults. The objective of the present study was to provide evidence on the SARS-CoV-2 seroprevalence among young adults in Germany and to explore determinants associated with seropositivity in general and, specifically, with previously undetected infections. STUDY DESIGN: This was a population-based SARS-CoV-2 seroprevalence study. METHODS: In November 2020, a population-based study on SARS-CoV-2 seroprevalence in young adults (aged 18–30 years) was conducted in a large German city. Serum samples were obtained to analyse the SARS-CoV-2 antibody status using the Elecsys Anti-SARS-CoV-2 immunoassay. Descriptive statistics and odds ratios (ORs) of seropositivity and of previously undetected infections in relation to different determinants were calculated. RESULTS: Among 2186 participants, SARS-CoV-2 antibodies were detected in 72 individuals, equalling a test performance-adjusted seroprevalence of 3.1% (95% confidence interval [CI]: 2.4–4.0). Based on reported COVID-19 cases to the public health authority, a moderate underascertainment rate of 1.7 was calculated. Seropositivity was higher among individuals who sought COVID-19-related information from social media (OR: 1.83, 95% CI: 1.2–3.1), and undetected COVID-19 infections were more prevalent among men and those not adhering to social distancing. CONCLUSIONS: The results show a substantial underascertainment of SARS-CoV-2 infections among young adults and indicate that seroprevalence is likely to be much higher than the reported COVID-19 prevalence based on confirmed COVID-19 cases in Germany. Preventive efforts should consider the heterogeneity of risk profiles among the young adult population. The Royal Society for Public Health. Published by Elsevier Ltd. 2022-06 2022-03-23 /pmc/articles/PMC8940565/ /pubmed/35490440 http://dx.doi.org/10.1016/j.puhe.2022.03.009 Text en © 2022 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Research Backhaus, I. Hermsen, D. Timm, J. Boege, F. Lübke, N. Degode, T. Göbels, K. Dragano, N. SARS-CoV-2 seroprevalence and determinants of infection in young adults: a population-based seroepidemiological study |
title | SARS-CoV-2 seroprevalence and determinants of infection in young adults: a population-based seroepidemiological study |
title_full | SARS-CoV-2 seroprevalence and determinants of infection in young adults: a population-based seroepidemiological study |
title_fullStr | SARS-CoV-2 seroprevalence and determinants of infection in young adults: a population-based seroepidemiological study |
title_full_unstemmed | SARS-CoV-2 seroprevalence and determinants of infection in young adults: a population-based seroepidemiological study |
title_short | SARS-CoV-2 seroprevalence and determinants of infection in young adults: a population-based seroepidemiological study |
title_sort | sars-cov-2 seroprevalence and determinants of infection in young adults: a population-based seroepidemiological study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940565/ https://www.ncbi.nlm.nih.gov/pubmed/35490440 http://dx.doi.org/10.1016/j.puhe.2022.03.009 |
work_keys_str_mv | AT backhausi sarscov2seroprevalenceanddeterminantsofinfectioninyoungadultsapopulationbasedseroepidemiologicalstudy AT hermsend sarscov2seroprevalenceanddeterminantsofinfectioninyoungadultsapopulationbasedseroepidemiologicalstudy AT timmj sarscov2seroprevalenceanddeterminantsofinfectioninyoungadultsapopulationbasedseroepidemiologicalstudy AT boegef sarscov2seroprevalenceanddeterminantsofinfectioninyoungadultsapopulationbasedseroepidemiologicalstudy AT lubken sarscov2seroprevalenceanddeterminantsofinfectioninyoungadultsapopulationbasedseroepidemiologicalstudy AT degodet sarscov2seroprevalenceanddeterminantsofinfectioninyoungadultsapopulationbasedseroepidemiologicalstudy AT gobelsk sarscov2seroprevalenceanddeterminantsofinfectioninyoungadultsapopulationbasedseroepidemiologicalstudy AT draganon sarscov2seroprevalenceanddeterminantsofinfectioninyoungadultsapopulationbasedseroepidemiologicalstudy |