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Post–COVID-19 syndrome and humoral response association after 1 year in vaccinated and unvaccinated patients

OBJECTIVES: This study aimed to describe the impact of vaccination and the role of humoral responses on post–COVID-19 syndrome 1 year after the onset of SARS coronavirus type 2 (CoV-2). METHODS: This prospective study was conducted through interviews to investigate post–COVID-19 syndrome 6 and 12 mo...

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Autores principales: Peghin, Maddalena, De Martino, Maria, Palese, Alvisa, Gerussi, Valentina, Bontempo, Giulia, Graziano, Elena, Visintini, Erica, D'Elia, Denise, Dellai, Fabiana, Marrella, Francesco, Fabris, Martina, Curcio, Francesco, Sartor, Assunta, Isola, Miriam, Tascini, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940723/
https://www.ncbi.nlm.nih.gov/pubmed/35339673
http://dx.doi.org/10.1016/j.cmi.2022.03.016
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author Peghin, Maddalena
De Martino, Maria
Palese, Alvisa
Gerussi, Valentina
Bontempo, Giulia
Graziano, Elena
Visintini, Erica
D'Elia, Denise
Dellai, Fabiana
Marrella, Francesco
Fabris, Martina
Curcio, Francesco
Sartor, Assunta
Isola, Miriam
Tascini, Carlo
author_facet Peghin, Maddalena
De Martino, Maria
Palese, Alvisa
Gerussi, Valentina
Bontempo, Giulia
Graziano, Elena
Visintini, Erica
D'Elia, Denise
Dellai, Fabiana
Marrella, Francesco
Fabris, Martina
Curcio, Francesco
Sartor, Assunta
Isola, Miriam
Tascini, Carlo
author_sort Peghin, Maddalena
collection PubMed
description OBJECTIVES: This study aimed to describe the impact of vaccination and the role of humoral responses on post–COVID-19 syndrome 1 year after the onset of SARS coronavirus type 2 (CoV-2). METHODS: This prospective study was conducted through interviews to investigate post–COVID-19 syndrome 6 and 12 months after disease onset in all adult in- and outpatients with COVID-19 at Udine Hospital (March–May 2020). Vaccination status and two different serological assays to distinguish between response to vaccination (receptor-binding domain (RBD) SARS-CoV-2 IgG) and/or natural infection (non-RBD-SARS-CoV-2 IgG) were also assessed. RESULTS: A total of 479 patients (52.6% female; mean age: 53 years) were interviewed 13.5 months (standard deviation: 0.6 months) after acute infection. Post–COVID-19 syndrome was observed in 47.2% of patients (n = 226) after 1 year. There were no significant differences in the worsening of post–COVID-19 symptoms (22.7% vs. 15.8%; p = 0.209) among vaccinated (n = 132) and unvaccinated (n = 347) patients. The presence of non-RBD SARS-CoV-2 IgG induced by natural infection showed a significant association with post–COVID-19 syndrome (OR: 1.35; 95% CI, 1.11–1.64; p = 0.003), and median non-RBD SARS-CoV-2 IgG titres were significantly higher in long haulers than in patients without symptoms (22 kAU/L (interquartile range, 9.7–37.2 kAU/L) vs. 14.1 kAU/L (interquartile range, 5.4–31.3 kAU/L); p = 0.009) after 1 year. In contrast, the presence of RBD SARS-CoV-2 IgG was not associated with the occurrence of post–COVID-19 syndrome (>2500 U/mL vs. 0.9–2500 U/mL; OR: 1.36; 95% CI, 0.62–3.00; p = 0.441), and RBD SARS-CoV-2 IgG titres were similar in long haulers as in patients without symptoms (50% values > 2500 U/mL vs. 55.6% values > 2500 U/mL; p = 0.451). DISCUSSION: The SARS-CoV-2 vaccination is not associated with the emergence of post–COVID-19 symptoms more than 1 year after acute infection. The persistence of high serological titre response induced by natural infection, but not vaccination, may play a role in long-haul COVID-19.
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spelling pubmed-89407232022-03-23 Post–COVID-19 syndrome and humoral response association after 1 year in vaccinated and unvaccinated patients Peghin, Maddalena De Martino, Maria Palese, Alvisa Gerussi, Valentina Bontempo, Giulia Graziano, Elena Visintini, Erica D'Elia, Denise Dellai, Fabiana Marrella, Francesco Fabris, Martina Curcio, Francesco Sartor, Assunta Isola, Miriam Tascini, Carlo Clin Microbiol Infect Original Article OBJECTIVES: This study aimed to describe the impact of vaccination and the role of humoral responses on post–COVID-19 syndrome 1 year after the onset of SARS coronavirus type 2 (CoV-2). METHODS: This prospective study was conducted through interviews to investigate post–COVID-19 syndrome 6 and 12 months after disease onset in all adult in- and outpatients with COVID-19 at Udine Hospital (March–May 2020). Vaccination status and two different serological assays to distinguish between response to vaccination (receptor-binding domain (RBD) SARS-CoV-2 IgG) and/or natural infection (non-RBD-SARS-CoV-2 IgG) were also assessed. RESULTS: A total of 479 patients (52.6% female; mean age: 53 years) were interviewed 13.5 months (standard deviation: 0.6 months) after acute infection. Post–COVID-19 syndrome was observed in 47.2% of patients (n = 226) after 1 year. There were no significant differences in the worsening of post–COVID-19 symptoms (22.7% vs. 15.8%; p = 0.209) among vaccinated (n = 132) and unvaccinated (n = 347) patients. The presence of non-RBD SARS-CoV-2 IgG induced by natural infection showed a significant association with post–COVID-19 syndrome (OR: 1.35; 95% CI, 1.11–1.64; p = 0.003), and median non-RBD SARS-CoV-2 IgG titres were significantly higher in long haulers than in patients without symptoms (22 kAU/L (interquartile range, 9.7–37.2 kAU/L) vs. 14.1 kAU/L (interquartile range, 5.4–31.3 kAU/L); p = 0.009) after 1 year. In contrast, the presence of RBD SARS-CoV-2 IgG was not associated with the occurrence of post–COVID-19 syndrome (>2500 U/mL vs. 0.9–2500 U/mL; OR: 1.36; 95% CI, 0.62–3.00; p = 0.441), and RBD SARS-CoV-2 IgG titres were similar in long haulers as in patients without symptoms (50% values > 2500 U/mL vs. 55.6% values > 2500 U/mL; p = 0.451). DISCUSSION: The SARS-CoV-2 vaccination is not associated with the emergence of post–COVID-19 symptoms more than 1 year after acute infection. The persistence of high serological titre response induced by natural infection, but not vaccination, may play a role in long-haul COVID-19. European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. 2022-08 2022-03-23 /pmc/articles/PMC8940723/ /pubmed/35339673 http://dx.doi.org/10.1016/j.cmi.2022.03.016 Text en © 2022 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Peghin, Maddalena
De Martino, Maria
Palese, Alvisa
Gerussi, Valentina
Bontempo, Giulia
Graziano, Elena
Visintini, Erica
D'Elia, Denise
Dellai, Fabiana
Marrella, Francesco
Fabris, Martina
Curcio, Francesco
Sartor, Assunta
Isola, Miriam
Tascini, Carlo
Post–COVID-19 syndrome and humoral response association after 1 year in vaccinated and unvaccinated patients
title Post–COVID-19 syndrome and humoral response association after 1 year in vaccinated and unvaccinated patients
title_full Post–COVID-19 syndrome and humoral response association after 1 year in vaccinated and unvaccinated patients
title_fullStr Post–COVID-19 syndrome and humoral response association after 1 year in vaccinated and unvaccinated patients
title_full_unstemmed Post–COVID-19 syndrome and humoral response association after 1 year in vaccinated and unvaccinated patients
title_short Post–COVID-19 syndrome and humoral response association after 1 year in vaccinated and unvaccinated patients
title_sort post–covid-19 syndrome and humoral response association after 1 year in vaccinated and unvaccinated patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940723/
https://www.ncbi.nlm.nih.gov/pubmed/35339673
http://dx.doi.org/10.1016/j.cmi.2022.03.016
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