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A Mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing

Bacterial infection is a vital factor to delay the wound healing process. The antibiotics abuse leads to drug resistance of some pathogenic bacteria. Non-antibiotic-dependent multifunctional biomaterials with accelerated wound healing performance are urgently desired. Herein, we reported a composite...

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Detalles Bibliográficos
Autores principales: Guo, Zhaoyuan, Zhang, Zhuangzhuang, Zhang, Nan, Gao, Wenxia, Li, Jing, Pu, Yuji, He, Bin, Xie, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940763/
https://www.ncbi.nlm.nih.gov/pubmed/35386343
http://dx.doi.org/10.1016/j.bioactmat.2021.11.036
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author Guo, Zhaoyuan
Zhang, Zhuangzhuang
Zhang, Nan
Gao, Wenxia
Li, Jing
Pu, Yuji
He, Bin
Xie, Jing
author_facet Guo, Zhaoyuan
Zhang, Zhuangzhuang
Zhang, Nan
Gao, Wenxia
Li, Jing
Pu, Yuji
He, Bin
Xie, Jing
author_sort Guo, Zhaoyuan
collection PubMed
description Bacterial infection is a vital factor to delay the wound healing process. The antibiotics abuse leads to drug resistance of some pathogenic bacteria. Non-antibiotic-dependent multifunctional biomaterials with accelerated wound healing performance are urgently desired. Herein, we reported a composite antibacterial hydrogel PDA-PAM/Mg(2+) that shows excellent self-healing and tissue adhesive property, and photothermal antibacterial functions for accelerating wound healing. The gel was composed of polyacrylamide (PAM), polydopamine (PDA), and magnesium (Mg(2+)) and prepared via a two-step procedure: an alkali-induced dopamine pre-polymerization and followed radical polymerization process. The composite gel shows excellent tissue adhesiveness and Mg(2+)-synergized photothermal antibacterial activity, inducing a survival rate of 5.29% for S. aureus and 7.06% for E. coli after near infrared light irradiation. The composite hydrogel further demonstrated efficient bacteria inhibition, enhanced wound healing and collagen deposition in a full-thickness skin defect rat model. Together, the PDA-PAM/Mg(2+) hydrogel presents an excellent wound dressing with excellent tissue adhesion, wound healing, and antibacterial functions.
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spelling pubmed-89407632022-04-05 A Mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing Guo, Zhaoyuan Zhang, Zhuangzhuang Zhang, Nan Gao, Wenxia Li, Jing Pu, Yuji He, Bin Xie, Jing Bioact Mater Article Bacterial infection is a vital factor to delay the wound healing process. The antibiotics abuse leads to drug resistance of some pathogenic bacteria. Non-antibiotic-dependent multifunctional biomaterials with accelerated wound healing performance are urgently desired. Herein, we reported a composite antibacterial hydrogel PDA-PAM/Mg(2+) that shows excellent self-healing and tissue adhesive property, and photothermal antibacterial functions for accelerating wound healing. The gel was composed of polyacrylamide (PAM), polydopamine (PDA), and magnesium (Mg(2+)) and prepared via a two-step procedure: an alkali-induced dopamine pre-polymerization and followed radical polymerization process. The composite gel shows excellent tissue adhesiveness and Mg(2+)-synergized photothermal antibacterial activity, inducing a survival rate of 5.29% for S. aureus and 7.06% for E. coli after near infrared light irradiation. The composite hydrogel further demonstrated efficient bacteria inhibition, enhanced wound healing and collagen deposition in a full-thickness skin defect rat model. Together, the PDA-PAM/Mg(2+) hydrogel presents an excellent wound dressing with excellent tissue adhesion, wound healing, and antibacterial functions. KeAi Publishing 2021-12-20 /pmc/articles/PMC8940763/ /pubmed/35386343 http://dx.doi.org/10.1016/j.bioactmat.2021.11.036 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Guo, Zhaoyuan
Zhang, Zhuangzhuang
Zhang, Nan
Gao, Wenxia
Li, Jing
Pu, Yuji
He, Bin
Xie, Jing
A Mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing
title A Mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing
title_full A Mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing
title_fullStr A Mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing
title_full_unstemmed A Mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing
title_short A Mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing
title_sort mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940763/
https://www.ncbi.nlm.nih.gov/pubmed/35386343
http://dx.doi.org/10.1016/j.bioactmat.2021.11.036
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