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A Mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing
Bacterial infection is a vital factor to delay the wound healing process. The antibiotics abuse leads to drug resistance of some pathogenic bacteria. Non-antibiotic-dependent multifunctional biomaterials with accelerated wound healing performance are urgently desired. Herein, we reported a composite...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940763/ https://www.ncbi.nlm.nih.gov/pubmed/35386343 http://dx.doi.org/10.1016/j.bioactmat.2021.11.036 |
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author | Guo, Zhaoyuan Zhang, Zhuangzhuang Zhang, Nan Gao, Wenxia Li, Jing Pu, Yuji He, Bin Xie, Jing |
author_facet | Guo, Zhaoyuan Zhang, Zhuangzhuang Zhang, Nan Gao, Wenxia Li, Jing Pu, Yuji He, Bin Xie, Jing |
author_sort | Guo, Zhaoyuan |
collection | PubMed |
description | Bacterial infection is a vital factor to delay the wound healing process. The antibiotics abuse leads to drug resistance of some pathogenic bacteria. Non-antibiotic-dependent multifunctional biomaterials with accelerated wound healing performance are urgently desired. Herein, we reported a composite antibacterial hydrogel PDA-PAM/Mg(2+) that shows excellent self-healing and tissue adhesive property, and photothermal antibacterial functions for accelerating wound healing. The gel was composed of polyacrylamide (PAM), polydopamine (PDA), and magnesium (Mg(2+)) and prepared via a two-step procedure: an alkali-induced dopamine pre-polymerization and followed radical polymerization process. The composite gel shows excellent tissue adhesiveness and Mg(2+)-synergized photothermal antibacterial activity, inducing a survival rate of 5.29% for S. aureus and 7.06% for E. coli after near infrared light irradiation. The composite hydrogel further demonstrated efficient bacteria inhibition, enhanced wound healing and collagen deposition in a full-thickness skin defect rat model. Together, the PDA-PAM/Mg(2+) hydrogel presents an excellent wound dressing with excellent tissue adhesion, wound healing, and antibacterial functions. |
format | Online Article Text |
id | pubmed-8940763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-89407632022-04-05 A Mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing Guo, Zhaoyuan Zhang, Zhuangzhuang Zhang, Nan Gao, Wenxia Li, Jing Pu, Yuji He, Bin Xie, Jing Bioact Mater Article Bacterial infection is a vital factor to delay the wound healing process. The antibiotics abuse leads to drug resistance of some pathogenic bacteria. Non-antibiotic-dependent multifunctional biomaterials with accelerated wound healing performance are urgently desired. Herein, we reported a composite antibacterial hydrogel PDA-PAM/Mg(2+) that shows excellent self-healing and tissue adhesive property, and photothermal antibacterial functions for accelerating wound healing. The gel was composed of polyacrylamide (PAM), polydopamine (PDA), and magnesium (Mg(2+)) and prepared via a two-step procedure: an alkali-induced dopamine pre-polymerization and followed radical polymerization process. The composite gel shows excellent tissue adhesiveness and Mg(2+)-synergized photothermal antibacterial activity, inducing a survival rate of 5.29% for S. aureus and 7.06% for E. coli after near infrared light irradiation. The composite hydrogel further demonstrated efficient bacteria inhibition, enhanced wound healing and collagen deposition in a full-thickness skin defect rat model. Together, the PDA-PAM/Mg(2+) hydrogel presents an excellent wound dressing with excellent tissue adhesion, wound healing, and antibacterial functions. KeAi Publishing 2021-12-20 /pmc/articles/PMC8940763/ /pubmed/35386343 http://dx.doi.org/10.1016/j.bioactmat.2021.11.036 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Guo, Zhaoyuan Zhang, Zhuangzhuang Zhang, Nan Gao, Wenxia Li, Jing Pu, Yuji He, Bin Xie, Jing A Mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing |
title | A Mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing |
title_full | A Mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing |
title_fullStr | A Mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing |
title_full_unstemmed | A Mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing |
title_short | A Mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing |
title_sort | mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940763/ https://www.ncbi.nlm.nih.gov/pubmed/35386343 http://dx.doi.org/10.1016/j.bioactmat.2021.11.036 |
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