A metabolically stable PET tracer for imaging synaptic vesicle protein 2A: synthesis and preclinical characterization of [(18)F]SDM-16

PURPOSE: To quantify the synaptic vesicle glycoprotein 2A (SV2A) changes in the whole central nervous system (CNS) under pathophysiological conditions, a high affinity SV2A PET radiotracer with improved in vivo stability is desirable to minimize the potential confounding effect of radiometabolites....

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Detalles Bibliográficos
Autores principales: Zheng, Chao, Holden, Daniel, Zheng, Ming-Qiang, Pracitto, Richard, Wilcox, Kyle C., Lindemann, Marcel, Felchner, Zachary, Zhang, Li, Tong, Jie, Fowles, Krista, Finnema, Sjoerd J., Nabulsi, Nabeel, Carson, Richard E., Huang, Yiyun, Cai, Zhengxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940841/
https://www.ncbi.nlm.nih.gov/pubmed/34761284
http://dx.doi.org/10.1007/s00259-021-05597-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940841/
https://www.ncbi.nlm.nih.gov/pubmed/34761284
http://dx.doi.org/10.1007/s00259-021-05597-5

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