Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics

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Therapeutic mRNAs and vaccines are being developed for a broad range of human diseases, including COVID-19. However, their optimization is hindered by mRNA instability and inefficient protein expression. Here, we describe design principles that overcome these barriers. We develop an RNA sequencing-b...

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Detalles Bibliográficos
Autores principales: Leppek, Kathrin, Byeon, Gun Woo, Kladwang, Wipapat, Wayment-Steele, Hannah K., Kerr, Craig H., Xu, Adele F., Kim, Do Soon, Topkar, Ved V., Choe, Christian, Rothschild, Daphna, Tiu, Gerald C., Wellington-Oguri, Roger, Fujii, Kotaro, Sharma, Eesha, Watkins, Andrew M., Nicol, John J., Romano, Jonathan, Tunguz, Bojan, Diaz, Fernando, Cai, Hui, Guo, Pengbo, Wu, Jiewei, Meng, Fanyu, Shi, Shuai, Participants, Eterna, Dormitzer, Philip R., Solórzano, Alicia, Barna, Maria, Das, Rhiju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940940/
https://www.ncbi.nlm.nih.gov/pubmed/35318324
http://dx.doi.org/10.1038/s41467-022-28776-w
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