GIT1 protects against breast cancer growth through negative regulation of Notch

Hyperactive Notch signalling is frequently observed in breast cancer and correlates with poor prognosis. However, relatively few mutations in the core Notch signalling pathway have been identified in breast cancer, suggesting that as yet unknown mechanisms increase Notch activity. Here we show that...

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Detalles Bibliográficos
Autores principales: Zhang, Songbai, Miyakawa, Ayako, Wickström, Malin, Dyberg, Cecilia, Louhivuori, Lauri, Varas-Godoy, Manuel, Kemppainen, Kati, Kanatani, Shigeaki, Kaczynska, Dagmara, Ellström, Ivar Dehnisch, Elfman, Lotta, Kronqvist, Pauliina, Repo, Heli, Mikoshiba, Katsuhiko, Sahlgren, Cecilia, Johnsen, John Inge, Uhlén, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940956/
https://www.ncbi.nlm.nih.gov/pubmed/35318302
http://dx.doi.org/10.1038/s41467-022-28631-y

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