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Single dose oral pharmacokinetic profile rubraxanthone in mice
Rubraxanthone is a main active constituent of kandis (Garcinia cowa Roxb), has showed many biological activity including antimicrobial, anti hypercholesterolemic, antiplatelet, antioxidant, cytotoxic, and anti-inflammatory properties. To the best of our knowledge, no reports on the pharmacokinetics...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941156/ https://www.ncbi.nlm.nih.gov/pubmed/35342834 http://dx.doi.org/10.1016/j.heliyon.2022.e09104 |
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author | Susanti, Meri Darmianti, Riski Harahap, Yahdiana Itam, Afrizal Hamidi, Dachriyanus |
author_facet | Susanti, Meri Darmianti, Riski Harahap, Yahdiana Itam, Afrizal Hamidi, Dachriyanus |
author_sort | Susanti, Meri |
collection | PubMed |
description | Rubraxanthone is a main active constituent of kandis (Garcinia cowa Roxb), has showed many biological activity including antimicrobial, anti hypercholesterolemic, antiplatelet, antioxidant, cytotoxic, and anti-inflammatory properties. To the best of our knowledge, no reports on the pharmacokinetics (PK) of this rubraxanthone have been published. The PK of rubraxanthone in mice was examined after a single oral dose of 700 mg/kg rubraxanthone suspension in virgin coconut oil. Plasma samples were collected at different time points and further analyzed using validated chromatographic method. Pharmacokinetic parameters were calculated from observed plasma concentration-time profile. The maximum concentration of rubraxanthone in plasma was discovered in 1.5 h. The peak plasma concentration (C(max)) was 4.267 μg/mL, and the area under the curve (AUCt0-t [Formula: see text]) was 560.99 μg h/L, with a 6.72-hour terminal half-life (T(1/2)). The volume of distribution (Vd/F) was 1200.19 mL/kg and 1123.88 mL/h/kg clearance (Cl/F). |
format | Online Article Text |
id | pubmed-8941156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-89411562022-03-24 Single dose oral pharmacokinetic profile rubraxanthone in mice Susanti, Meri Darmianti, Riski Harahap, Yahdiana Itam, Afrizal Hamidi, Dachriyanus Heliyon Research Article Rubraxanthone is a main active constituent of kandis (Garcinia cowa Roxb), has showed many biological activity including antimicrobial, anti hypercholesterolemic, antiplatelet, antioxidant, cytotoxic, and anti-inflammatory properties. To the best of our knowledge, no reports on the pharmacokinetics (PK) of this rubraxanthone have been published. The PK of rubraxanthone in mice was examined after a single oral dose of 700 mg/kg rubraxanthone suspension in virgin coconut oil. Plasma samples were collected at different time points and further analyzed using validated chromatographic method. Pharmacokinetic parameters were calculated from observed plasma concentration-time profile. The maximum concentration of rubraxanthone in plasma was discovered in 1.5 h. The peak plasma concentration (C(max)) was 4.267 μg/mL, and the area under the curve (AUCt0-t [Formula: see text]) was 560.99 μg h/L, with a 6.72-hour terminal half-life (T(1/2)). The volume of distribution (Vd/F) was 1200.19 mL/kg and 1123.88 mL/h/kg clearance (Cl/F). Elsevier 2022-03-14 /pmc/articles/PMC8941156/ /pubmed/35342834 http://dx.doi.org/10.1016/j.heliyon.2022.e09104 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Susanti, Meri Darmianti, Riski Harahap, Yahdiana Itam, Afrizal Hamidi, Dachriyanus Single dose oral pharmacokinetic profile rubraxanthone in mice |
title | Single dose oral pharmacokinetic profile rubraxanthone in mice |
title_full | Single dose oral pharmacokinetic profile rubraxanthone in mice |
title_fullStr | Single dose oral pharmacokinetic profile rubraxanthone in mice |
title_full_unstemmed | Single dose oral pharmacokinetic profile rubraxanthone in mice |
title_short | Single dose oral pharmacokinetic profile rubraxanthone in mice |
title_sort | single dose oral pharmacokinetic profile rubraxanthone in mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941156/ https://www.ncbi.nlm.nih.gov/pubmed/35342834 http://dx.doi.org/10.1016/j.heliyon.2022.e09104 |
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