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A case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare manifestation of malignancy. The antemortem diagnosis is difficult, since patients present with rapidly progressive symptoms. We recently observed a case of PTTM following lymphedema of the lower extremities. We did not reach a diagnosis, e...

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Autores principales: Shiraiwa, Yuri, Taniguchi, Yuri, Hyoudou, Mari, Shiba, Aya, Aga, Masaharu, Miyazaki, Kazuhito, Hamakawa, Yusuke, Misumi, Yuki, Agemi, Yoko, Shimokawa, Tsuneo, Hasegawa, Chie, Hayashi, Hiroyuki, Okamoto, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941268/
https://www.ncbi.nlm.nih.gov/pubmed/35342709
http://dx.doi.org/10.1016/j.rmcr.2022.101631
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author Shiraiwa, Yuri
Taniguchi, Yuri
Hyoudou, Mari
Shiba, Aya
Aga, Masaharu
Miyazaki, Kazuhito
Hamakawa, Yusuke
Misumi, Yuki
Agemi, Yoko
Shimokawa, Tsuneo
Hasegawa, Chie
Hayashi, Hiroyuki
Okamoto, Hiroaki
author_facet Shiraiwa, Yuri
Taniguchi, Yuri
Hyoudou, Mari
Shiba, Aya
Aga, Masaharu
Miyazaki, Kazuhito
Hamakawa, Yusuke
Misumi, Yuki
Agemi, Yoko
Shimokawa, Tsuneo
Hasegawa, Chie
Hayashi, Hiroyuki
Okamoto, Hiroaki
author_sort Shiraiwa, Yuri
collection PubMed
description Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare manifestation of malignancy. The antemortem diagnosis is difficult, since patients present with rapidly progressive symptoms. We recently observed a case of PTTM following lymphedema of the lower extremities. We did not reach a diagnosis, even after performing BAL and TBLB. The patient manifested pulmonary hypertension and died on the 9th day of admission. Autopsy revealed a tumor embolism in the pulmonary arterioles accompanied by fibrocellular epithelial cell proliferation, but the primary organ was not identified. To our knowledge, this is the first reported case of PTTM with lymphedema.
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spelling pubmed-89412682022-03-24 A case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities Shiraiwa, Yuri Taniguchi, Yuri Hyoudou, Mari Shiba, Aya Aga, Masaharu Miyazaki, Kazuhito Hamakawa, Yusuke Misumi, Yuki Agemi, Yoko Shimokawa, Tsuneo Hasegawa, Chie Hayashi, Hiroyuki Okamoto, Hiroaki Respir Med Case Rep Case Report Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare manifestation of malignancy. The antemortem diagnosis is difficult, since patients present with rapidly progressive symptoms. We recently observed a case of PTTM following lymphedema of the lower extremities. We did not reach a diagnosis, even after performing BAL and TBLB. The patient manifested pulmonary hypertension and died on the 9th day of admission. Autopsy revealed a tumor embolism in the pulmonary arterioles accompanied by fibrocellular epithelial cell proliferation, but the primary organ was not identified. To our knowledge, this is the first reported case of PTTM with lymphedema. Elsevier 2022-03-15 /pmc/articles/PMC8941268/ /pubmed/35342709 http://dx.doi.org/10.1016/j.rmcr.2022.101631 Text en © 2022 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Shiraiwa, Yuri
Taniguchi, Yuri
Hyoudou, Mari
Shiba, Aya
Aga, Masaharu
Miyazaki, Kazuhito
Hamakawa, Yusuke
Misumi, Yuki
Agemi, Yoko
Shimokawa, Tsuneo
Hasegawa, Chie
Hayashi, Hiroyuki
Okamoto, Hiroaki
A case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities
title A case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities
title_full A case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities
title_fullStr A case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities
title_full_unstemmed A case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities
title_short A case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities
title_sort case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941268/
https://www.ncbi.nlm.nih.gov/pubmed/35342709
http://dx.doi.org/10.1016/j.rmcr.2022.101631
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