Cargando…

Effect of collagen fibre orientation on the Poisson's ratio and stress relaxation of skin: an ex vivo and in vivo study

During surgical treatment skin undergoes extensive deformation, hence it must be able to withstand large mechanical stresses without damage. Therefore, understanding the mechanical properties of skin becomes important. A detailed investigation on the relationship between the three-dimensional deform...

Descripción completa

Detalles Bibliográficos
Autores principales: Dwivedi, Krashn Kumar, Lakhani, Piyush, Kumar, Sachin, Kumar, Navin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941416/
https://www.ncbi.nlm.nih.gov/pubmed/35345435
http://dx.doi.org/10.1098/rsos.211301
_version_ 1784673103321759744
author Dwivedi, Krashn Kumar
Lakhani, Piyush
Kumar, Sachin
Kumar, Navin
author_facet Dwivedi, Krashn Kumar
Lakhani, Piyush
Kumar, Sachin
Kumar, Navin
author_sort Dwivedi, Krashn Kumar
collection PubMed
description During surgical treatment skin undergoes extensive deformation, hence it must be able to withstand large mechanical stresses without damage. Therefore, understanding the mechanical properties of skin becomes important. A detailed investigation on the relationship between the three-dimensional deformation response of skin and its microstructure is conducted in the current study. This study also discloses the underlying science of skin viscoelasticity. Deformation response of skin is captured using digital image correlation, whereas micro-CT, scanning electron microscopy and atomic force microscopy are used for microstructure analysis. Skin shows a large lateral contraction and expansion (auxeticity) when stretched parallel and perpendicular to the skin tension lines, respectively. Large lateral contraction is a result of fluid exudation from the tissue, while large rotation of the stiff collagen fibres in the loading direction explains the skin auxeticity. During stress relaxation, lateral contraction and fluid effluxion from skin reveal that tissue volume loss is the intrinsic science of skin viscoelasticity. Furthermore, the results obtained from in vivo study on human skin show the relevance of the ex vivo study to physiological conditions and stretching of the skin during its treatments.
format Online
Article
Text
id pubmed-8941416
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Royal Society
record_format MEDLINE/PubMed
spelling pubmed-89414162022-03-27 Effect of collagen fibre orientation on the Poisson's ratio and stress relaxation of skin: an ex vivo and in vivo study Dwivedi, Krashn Kumar Lakhani, Piyush Kumar, Sachin Kumar, Navin R Soc Open Sci Engineering During surgical treatment skin undergoes extensive deformation, hence it must be able to withstand large mechanical stresses without damage. Therefore, understanding the mechanical properties of skin becomes important. A detailed investigation on the relationship between the three-dimensional deformation response of skin and its microstructure is conducted in the current study. This study also discloses the underlying science of skin viscoelasticity. Deformation response of skin is captured using digital image correlation, whereas micro-CT, scanning electron microscopy and atomic force microscopy are used for microstructure analysis. Skin shows a large lateral contraction and expansion (auxeticity) when stretched parallel and perpendicular to the skin tension lines, respectively. Large lateral contraction is a result of fluid exudation from the tissue, while large rotation of the stiff collagen fibres in the loading direction explains the skin auxeticity. During stress relaxation, lateral contraction and fluid effluxion from skin reveal that tissue volume loss is the intrinsic science of skin viscoelasticity. Furthermore, the results obtained from in vivo study on human skin show the relevance of the ex vivo study to physiological conditions and stretching of the skin during its treatments. The Royal Society 2022-03-23 /pmc/articles/PMC8941416/ /pubmed/35345435 http://dx.doi.org/10.1098/rsos.211301 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Engineering
Dwivedi, Krashn Kumar
Lakhani, Piyush
Kumar, Sachin
Kumar, Navin
Effect of collagen fibre orientation on the Poisson's ratio and stress relaxation of skin: an ex vivo and in vivo study
title Effect of collagen fibre orientation on the Poisson's ratio and stress relaxation of skin: an ex vivo and in vivo study
title_full Effect of collagen fibre orientation on the Poisson's ratio and stress relaxation of skin: an ex vivo and in vivo study
title_fullStr Effect of collagen fibre orientation on the Poisson's ratio and stress relaxation of skin: an ex vivo and in vivo study
title_full_unstemmed Effect of collagen fibre orientation on the Poisson's ratio and stress relaxation of skin: an ex vivo and in vivo study
title_short Effect of collagen fibre orientation on the Poisson's ratio and stress relaxation of skin: an ex vivo and in vivo study
title_sort effect of collagen fibre orientation on the poisson's ratio and stress relaxation of skin: an ex vivo and in vivo study
topic Engineering
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941416/
https://www.ncbi.nlm.nih.gov/pubmed/35345435
http://dx.doi.org/10.1098/rsos.211301
work_keys_str_mv AT dwivedikrashnkumar effectofcollagenfibreorientationonthepoissonsratioandstressrelaxationofskinanexvivoandinvivostudy
AT lakhanipiyush effectofcollagenfibreorientationonthepoissonsratioandstressrelaxationofskinanexvivoandinvivostudy
AT kumarsachin effectofcollagenfibreorientationonthepoissonsratioandstressrelaxationofskinanexvivoandinvivostudy
AT kumarnavin effectofcollagenfibreorientationonthepoissonsratioandstressrelaxationofskinanexvivoandinvivostudy