4-1BBL–containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells

Chronic and acute myeloid leukemia evade immune system surveillance and induce immunosuppression by expanding proleukemic Foxp3(+) regulatory T cells (Tregs). High levels of immunosuppressive Tregs predict inferior response to chemotherapy, leukemia relapse, and shorter survival. However, mechanisms...

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Detalles Bibliográficos
Autores principales: Swatler, Julian, Turos-Korgul, Laura, Brewinska-Olchowik, Marta, De Biasi, Sara, Dudka, Wioleta, Le, Bac Viet, Kominek, Agata, Cyranowski, Salwador, Pilanc, Paulina, Mohammadi, Elyas, Cysewski, Dominik, Kozlowska, Ewa, Grabowska-Pyrzewicz, Wioleta, Wojda, Urszula, Basak, Grzegorz, Mieczkowski, Jakub, Skorski, Tomasz, Cossarizza, Andrea, Piwocka, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Immunobiology and Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941461/
https://www.ncbi.nlm.nih.gov/pubmed/35130345
http://dx.doi.org/10.1182/bloodadvances.2021006195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941461/
https://www.ncbi.nlm.nih.gov/pubmed/35130345
http://dx.doi.org/10.1182/bloodadvances.2021006195

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