Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for CSNK1A1 in clonal expansion

How genetic haploinsufficiency contributes to the clonal dominance of hematopoietic stem cells (HSCs) in del(5q) myelodysplastic syndrome (MDS) remains unresolved. Using a genetic barcoding strategy, we performed a systematic comparison on genes implicated in the pathogenesis of del(5q) MDS in direc...

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Detalles Bibliográficos
Autores principales: Stalmann, Ursula S. A., Ticconi, Fabio, Snoeren, Inge A. M., Li, Ronghui, Gleitz, Hélène F. E., Cowley, Glenn S., McConkey, Marie E., Wong, Aaron B., Schmitz, Stephani, Fuchs, Stijn N. R., Sood, Shubhankar, Leimkühler, Nils B., Martinez-Høyer, Sergio, Banjanin, Bella, Root, David, Brümmendorf, Tim H., Pearce, Juliette E., Schuppert, Andreas, Bindels, Eric M. J., Essers, Marieke A., Heckl, Dirk, Stiehl, Thomas, Costa, Ivan G., Ebert, Benjamin L., Schneider, Rebekka K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941465/
https://www.ncbi.nlm.nih.gov/pubmed/35016204
http://dx.doi.org/10.1182/bloodadvances.2021006061

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