Hypermethylation at the CXCR5 gene locus limits trafficking potential of CD8(+) T cells into B-cell follicles during HIV-1 infection

CD8(+) T cells play an important role in HIV control. However, in human lymph nodes (LNs), only a small subset of CD8(+) T cells express CXCR5, the chemokine receptor required for cell migration into B-cell follicles, which are major sanctuaries for HIV persistence in individuals on therapy. Here, w...

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Detalles Bibliográficos
Autores principales: Ogunshola, Funsho J., Smidt, Werner, Naidoo, Anneta F., Nkosi, Thandeka, Ngubane, Thandekile, Khaba, Trevor, Baiyegunhi, Omolara O., Mahlobo, Bongiwe, Rasehlo, Sam, Ngema, Namani, Jajbhay, Ismail, Dong, Krista L., Ramsuran, Veron, Pansegrouw, Johan, Ndung’u, Thumbi, Walker, Bruce D., de Oliveria, Tulio, Ndhlovu, Zaza M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Immunobiology and Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941472/
https://www.ncbi.nlm.nih.gov/pubmed/34991160
http://dx.doi.org/10.1182/bloodadvances.2021006001

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