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Plasma-Derived HIV-1 Virions Contain Considerable Levels of Defective Genomes

Genetically-characterizing full-length HIV-1 RNA is critical for identifying genetically-intact genomes and for comparing these RNA genomes to proviral DNA. We have developed a method for sequencing plasma-derived RNA using long-range sequencing (PRLS assay; ∼8.3 kb from gag to the 3′ end or ∼5 kb f...

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Detalles Bibliográficos
Autores principales:	Fisher, Katie, Wang, Xiao Qian, Lee, Ashley, Morcilla, Vincent, de Vries, Anneke, Lee, Eunok, Eden, John-Sebastian, Deeks, Steven G., Kelleher, Anthony D., Palmer, Sarah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Genetic Diversity and Evolution
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941922/ https://www.ncbi.nlm.nih.gov/pubmed/35201897 http://dx.doi.org/10.1128/jvi.02011-21

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