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Fatigue in chronic liver disease patients: prevalence, pathophysiology, and management

Fatigue is the most commonly encountered symptom in patients with chronic liver disease (CLD). The resulting decrease in quality of life contributes markedly to the societal costs of fatigue. Moreover, fatigue is associated with social dysfunction, increased daytime somnolence, impaired working abil...

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Autores principales: Kośnik, Artur, Wójcicki, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942008/
https://www.ncbi.nlm.nih.gov/pubmed/35371364
http://dx.doi.org/10.5114/pg.2022.114594
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author Kośnik, Artur
Wójcicki, Maciej
author_facet Kośnik, Artur
Wójcicki, Maciej
author_sort Kośnik, Artur
collection PubMed
description Fatigue is the most commonly encountered symptom in patients with chronic liver disease (CLD). The resulting decrease in quality of life contributes markedly to the societal costs of fatigue. Moreover, fatigue is associated with social dysfunction, increased daytime somnolence, impaired working ability, and increased risk of mortality. Fatigue is not related to the severity of the underlying liver fibrosis or dysfunction. In CLD patients, fatigue manifests with both central symptoms, characterised by cognitive impairment, sleep disturbance, apathy, and autonomic dysfunction, and peripheral symptoms, characterised by decreased exercise tolerance and reduced physical activity levels. The pathogenesis of fatigue in CLD is multifactorial and involves changes in the brain–liver axis resulting from changes in inflammatory cytokines or the gut microbiome. Numerous interventions have attempted to alleviate fatigue in CLD by improving its central and peripheral manifestations or the underlying liver disease. Currently, however, there are no widely accepted or effective treatments for fatigue in CLD patients. In this review, we highlight the problem of fatigue in CLD, the current theories regarding its pathogenesis, and current approaches to its treatment.
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spelling pubmed-89420082022-03-31 Fatigue in chronic liver disease patients: prevalence, pathophysiology, and management Kośnik, Artur Wójcicki, Maciej Prz Gastroenterol Review Paper Fatigue is the most commonly encountered symptom in patients with chronic liver disease (CLD). The resulting decrease in quality of life contributes markedly to the societal costs of fatigue. Moreover, fatigue is associated with social dysfunction, increased daytime somnolence, impaired working ability, and increased risk of mortality. Fatigue is not related to the severity of the underlying liver fibrosis or dysfunction. In CLD patients, fatigue manifests with both central symptoms, characterised by cognitive impairment, sleep disturbance, apathy, and autonomic dysfunction, and peripheral symptoms, characterised by decreased exercise tolerance and reduced physical activity levels. The pathogenesis of fatigue in CLD is multifactorial and involves changes in the brain–liver axis resulting from changes in inflammatory cytokines or the gut microbiome. Numerous interventions have attempted to alleviate fatigue in CLD by improving its central and peripheral manifestations or the underlying liver disease. Currently, however, there are no widely accepted or effective treatments for fatigue in CLD patients. In this review, we highlight the problem of fatigue in CLD, the current theories regarding its pathogenesis, and current approaches to its treatment. Termedia Publishing House 2022-03-18 2022 /pmc/articles/PMC8942008/ /pubmed/35371364 http://dx.doi.org/10.5114/pg.2022.114594 Text en Copyright © 2022 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY -NC -SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ).This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) )
spellingShingle Review Paper
Kośnik, Artur
Wójcicki, Maciej
Fatigue in chronic liver disease patients: prevalence, pathophysiology, and management
title Fatigue in chronic liver disease patients: prevalence, pathophysiology, and management
title_full Fatigue in chronic liver disease patients: prevalence, pathophysiology, and management
title_fullStr Fatigue in chronic liver disease patients: prevalence, pathophysiology, and management
title_full_unstemmed Fatigue in chronic liver disease patients: prevalence, pathophysiology, and management
title_short Fatigue in chronic liver disease patients: prevalence, pathophysiology, and management
title_sort fatigue in chronic liver disease patients: prevalence, pathophysiology, and management
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942008/
https://www.ncbi.nlm.nih.gov/pubmed/35371364
http://dx.doi.org/10.5114/pg.2022.114594
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