Cargando…

Characteristics and Predictors of Long-Time Survivors in Non-Metastatic Gastric Signet Ring Cell Carcinoma: A Large Population-Based Study

OBJECTIVE: Gastric signet ring cell carcinoma (SRCC) is a distinct entity with a relatively poor prognosis. This study analyzed the clinicopathological characteristics of long-time survivors (LTSs) and identified independent predictors of long-term survival (LTS) in non-metastatic gastric SRCC. METH...

Descripción completa

Detalles Bibliográficos
Autores principales: Weng, Qiuyan, Li, Zhe, Xie, Yaoyao, Guo, Junming, Zhang, Yong, Ye, Guoliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942124/
https://www.ncbi.nlm.nih.gov/pubmed/35342298
http://dx.doi.org/10.2147/IJGM.S350448
_version_ 1784673239586308096
author Weng, Qiuyan
Li, Zhe
Xie, Yaoyao
Guo, Junming
Zhang, Yong
Ye, Guoliang
author_facet Weng, Qiuyan
Li, Zhe
Xie, Yaoyao
Guo, Junming
Zhang, Yong
Ye, Guoliang
author_sort Weng, Qiuyan
collection PubMed
description OBJECTIVE: Gastric signet ring cell carcinoma (SRCC) is a distinct entity with a relatively poor prognosis. This study analyzed the clinicopathological characteristics of long-time survivors (LTSs) and identified independent predictors of long-term survival (LTS) in non-metastatic gastric SRCC. METHODS: Data from 3906 patients with non-metastatic gastric SRCC were retrieved from Surveillance, Epidemiology and End Results according to the inclusion and exclusion criteria. Patients were randomly divided into training and validation cohorts. Predictors of LTS in the training cohort were identified by multivariate logistic regression. A nomogram-based predictive model for LTS was constructed in non-metastatic gastric SRCC. RESULTS: There were 800 patients who survived for >5 years and were defined as TLSs. Young age, other race (not black or white population), female gender, married status, small tumor size, low tumor infiltration, and negative lymph node involvement were independent predictors of LTS in non-metastatic gastric SRCC. These seven variables were incorporated into a nomogram model for predicting LTS. The calibration curve showed good consistency between observed and predicted probability of LTS, and the receiver operating characteristic curve showed acceptable discriminative capacity in the training and validation cohorts. CONCLUSION: This study provides an overview of the features of patients with non-metastatic gastric SRCC. Age, race, sex, marital status, tumor size, tumor infiltration, and lymph node involvement were identified as independent predictors of LTS.
format Online
Article
Text
id pubmed-8942124
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-89421242022-03-24 Characteristics and Predictors of Long-Time Survivors in Non-Metastatic Gastric Signet Ring Cell Carcinoma: A Large Population-Based Study Weng, Qiuyan Li, Zhe Xie, Yaoyao Guo, Junming Zhang, Yong Ye, Guoliang Int J Gen Med Original Research OBJECTIVE: Gastric signet ring cell carcinoma (SRCC) is a distinct entity with a relatively poor prognosis. This study analyzed the clinicopathological characteristics of long-time survivors (LTSs) and identified independent predictors of long-term survival (LTS) in non-metastatic gastric SRCC. METHODS: Data from 3906 patients with non-metastatic gastric SRCC were retrieved from Surveillance, Epidemiology and End Results according to the inclusion and exclusion criteria. Patients were randomly divided into training and validation cohorts. Predictors of LTS in the training cohort were identified by multivariate logistic regression. A nomogram-based predictive model for LTS was constructed in non-metastatic gastric SRCC. RESULTS: There were 800 patients who survived for >5 years and were defined as TLSs. Young age, other race (not black or white population), female gender, married status, small tumor size, low tumor infiltration, and negative lymph node involvement were independent predictors of LTS in non-metastatic gastric SRCC. These seven variables were incorporated into a nomogram model for predicting LTS. The calibration curve showed good consistency between observed and predicted probability of LTS, and the receiver operating characteristic curve showed acceptable discriminative capacity in the training and validation cohorts. CONCLUSION: This study provides an overview of the features of patients with non-metastatic gastric SRCC. Age, race, sex, marital status, tumor size, tumor infiltration, and lymph node involvement were identified as independent predictors of LTS. Dove 2022-03-19 /pmc/articles/PMC8942124/ /pubmed/35342298 http://dx.doi.org/10.2147/IJGM.S350448 Text en © 2022 Weng et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Weng, Qiuyan
Li, Zhe
Xie, Yaoyao
Guo, Junming
Zhang, Yong
Ye, Guoliang
Characteristics and Predictors of Long-Time Survivors in Non-Metastatic Gastric Signet Ring Cell Carcinoma: A Large Population-Based Study
title Characteristics and Predictors of Long-Time Survivors in Non-Metastatic Gastric Signet Ring Cell Carcinoma: A Large Population-Based Study
title_full Characteristics and Predictors of Long-Time Survivors in Non-Metastatic Gastric Signet Ring Cell Carcinoma: A Large Population-Based Study
title_fullStr Characteristics and Predictors of Long-Time Survivors in Non-Metastatic Gastric Signet Ring Cell Carcinoma: A Large Population-Based Study
title_full_unstemmed Characteristics and Predictors of Long-Time Survivors in Non-Metastatic Gastric Signet Ring Cell Carcinoma: A Large Population-Based Study
title_short Characteristics and Predictors of Long-Time Survivors in Non-Metastatic Gastric Signet Ring Cell Carcinoma: A Large Population-Based Study
title_sort characteristics and predictors of long-time survivors in non-metastatic gastric signet ring cell carcinoma: a large population-based study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942124/
https://www.ncbi.nlm.nih.gov/pubmed/35342298
http://dx.doi.org/10.2147/IJGM.S350448
work_keys_str_mv AT wengqiuyan characteristicsandpredictorsoflongtimesurvivorsinnonmetastaticgastricsignetringcellcarcinomaalargepopulationbasedstudy
AT lizhe characteristicsandpredictorsoflongtimesurvivorsinnonmetastaticgastricsignetringcellcarcinomaalargepopulationbasedstudy
AT xieyaoyao characteristicsandpredictorsoflongtimesurvivorsinnonmetastaticgastricsignetringcellcarcinomaalargepopulationbasedstudy
AT guojunming characteristicsandpredictorsoflongtimesurvivorsinnonmetastaticgastricsignetringcellcarcinomaalargepopulationbasedstudy
AT zhangyong characteristicsandpredictorsoflongtimesurvivorsinnonmetastaticgastricsignetringcellcarcinomaalargepopulationbasedstudy
AT yeguoliang characteristicsandpredictorsoflongtimesurvivorsinnonmetastaticgastricsignetringcellcarcinomaalargepopulationbasedstudy