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Hydrocephalus-Associated Hyponatremia: A Review
Hydrocephalus is the pathological accumulation of cerebrospinal fluid within the ventricles of the brain. Hydrocephalus may be broadly divided into three categories: congenital, acquired, or other. Hyponatremia, serum sodium level <135 meq/ml, may be caused by dilution (e.g. syndrome of inappropr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942136/ https://www.ncbi.nlm.nih.gov/pubmed/35371779 http://dx.doi.org/10.7759/cureus.22427 |
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author | Li, Chao Mabry, Iveth Khan, Yasir R Balsz, Michael Hanson, Rodolfo J Siddiqi, Javed |
author_facet | Li, Chao Mabry, Iveth Khan, Yasir R Balsz, Michael Hanson, Rodolfo J Siddiqi, Javed |
author_sort | Li, Chao |
collection | PubMed |
description | Hydrocephalus is the pathological accumulation of cerebrospinal fluid within the ventricles of the brain. Hydrocephalus may be broadly divided into three categories: congenital, acquired, or other. Hyponatremia, serum sodium level <135 meq/ml, may be caused by dilution (e.g. syndrome of inappropriate antidiuretic hormone (SIADH)), depletion (e.g. cerebral salt wasting (CSW)), or delusion (e.g. psychogenic water intake) etiologies. This review discusses “hydrocephalus-associated hyponatremia” as a clinical entity, distinct from SIADH and CSW. Some experts believe that in hydrocephalus patients, increased pressure on the hypothalamus leads to the release of antidiuretic hormone (ADH), which in turn causes hyponatremia. The true etiology of hyponatremia is critical to diagnose, as it will determine the treatment. So while both SIADH and CSW may result in hyponatremia, the former is treated with fluid restriction, while the latter requires fluid repletion; treating SIADH as CSW, and vice versa, will exacerbate the hyponatremia. The etiology and severity of hyponatremia will determine the management. For hydrocephalus-associated hyponatremia, treating the underlying problem (i.e. hydrocephalus) is the mainstay of therapy. Theoretically, treatment of hydrocephalus-related hyponatremia with CSF-diversion procedures should relieve the pressure on the hypothalamus, mitigating ADH production, which in turn will decrease sodium excretion and ameliorate the hyponatremia. |
format | Online Article Text |
id | pubmed-8942136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-89421362022-03-31 Hydrocephalus-Associated Hyponatremia: A Review Li, Chao Mabry, Iveth Khan, Yasir R Balsz, Michael Hanson, Rodolfo J Siddiqi, Javed Cureus Endocrinology/Diabetes/Metabolism Hydrocephalus is the pathological accumulation of cerebrospinal fluid within the ventricles of the brain. Hydrocephalus may be broadly divided into three categories: congenital, acquired, or other. Hyponatremia, serum sodium level <135 meq/ml, may be caused by dilution (e.g. syndrome of inappropriate antidiuretic hormone (SIADH)), depletion (e.g. cerebral salt wasting (CSW)), or delusion (e.g. psychogenic water intake) etiologies. This review discusses “hydrocephalus-associated hyponatremia” as a clinical entity, distinct from SIADH and CSW. Some experts believe that in hydrocephalus patients, increased pressure on the hypothalamus leads to the release of antidiuretic hormone (ADH), which in turn causes hyponatremia. The true etiology of hyponatremia is critical to diagnose, as it will determine the treatment. So while both SIADH and CSW may result in hyponatremia, the former is treated with fluid restriction, while the latter requires fluid repletion; treating SIADH as CSW, and vice versa, will exacerbate the hyponatremia. The etiology and severity of hyponatremia will determine the management. For hydrocephalus-associated hyponatremia, treating the underlying problem (i.e. hydrocephalus) is the mainstay of therapy. Theoretically, treatment of hydrocephalus-related hyponatremia with CSF-diversion procedures should relieve the pressure on the hypothalamus, mitigating ADH production, which in turn will decrease sodium excretion and ameliorate the hyponatremia. Cureus 2022-02-21 /pmc/articles/PMC8942136/ /pubmed/35371779 http://dx.doi.org/10.7759/cureus.22427 Text en Copyright © 2022, Li et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Endocrinology/Diabetes/Metabolism Li, Chao Mabry, Iveth Khan, Yasir R Balsz, Michael Hanson, Rodolfo J Siddiqi, Javed Hydrocephalus-Associated Hyponatremia: A Review |
title | Hydrocephalus-Associated Hyponatremia: A Review |
title_full | Hydrocephalus-Associated Hyponatremia: A Review |
title_fullStr | Hydrocephalus-Associated Hyponatremia: A Review |
title_full_unstemmed | Hydrocephalus-Associated Hyponatremia: A Review |
title_short | Hydrocephalus-Associated Hyponatremia: A Review |
title_sort | hydrocephalus-associated hyponatremia: a review |
topic | Endocrinology/Diabetes/Metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942136/ https://www.ncbi.nlm.nih.gov/pubmed/35371779 http://dx.doi.org/10.7759/cureus.22427 |
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