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Extraosseous Spread of Multiple Myeloma Mimicking Pancoast Tumor

A 55-year-old man presented with upper backache for one month, inability to move both the lower limbs for two weeks and retention of urine for five days. Examination revealed spastic paraplegia and reduced breath sounds in the right upper zone. Initial imaging revealed a soft tissue lesion in the ap...

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Autores principales: Bansal, Kuldeep, Singh, Sumedha, Gupta, Anuj, Chhabra, Harvinder Singh, Kalidindi, Kalyan Kumar Varma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942157/
https://www.ncbi.nlm.nih.gov/pubmed/35345749
http://dx.doi.org/10.7759/cureus.22412
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author Bansal, Kuldeep
Singh, Sumedha
Gupta, Anuj
Chhabra, Harvinder Singh
Kalidindi, Kalyan Kumar Varma
author_facet Bansal, Kuldeep
Singh, Sumedha
Gupta, Anuj
Chhabra, Harvinder Singh
Kalidindi, Kalyan Kumar Varma
author_sort Bansal, Kuldeep
collection PubMed
description A 55-year-old man presented with upper backache for one month, inability to move both the lower limbs for two weeks and retention of urine for five days. Examination revealed spastic paraplegia and reduced breath sounds in the right upper zone. Initial imaging revealed a soft tissue lesion in the apex of the right lung, suggesting a Pancoast tumor. It also showed a lytic, expansile lesion of the T2 vertebra extending to the right second posterior rib on subsequent imaging. High serum calcium, M-spike in beta-gamma globulin region on serum electrophoresis, 50%-60% plasmacytoid cells on bone marrow aspiration, concertina collapse of the vertebral body, and pattern of neurological deficit pointed towards multiple myeloma. T2 corpectomy and mesh cage placement, C7-T4 posterior stabilization, and resection of the second rib were done. Histopathology confirmed multiple myeloma. Postoperatively, the patient was managed with radiotherapy and bortezomib. The patient had a good neurological recovery. Timely intervention is critical for disease control and leads to better recovery.
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spelling pubmed-89421572022-03-27 Extraosseous Spread of Multiple Myeloma Mimicking Pancoast Tumor Bansal, Kuldeep Singh, Sumedha Gupta, Anuj Chhabra, Harvinder Singh Kalidindi, Kalyan Kumar Varma Cureus Radiology A 55-year-old man presented with upper backache for one month, inability to move both the lower limbs for two weeks and retention of urine for five days. Examination revealed spastic paraplegia and reduced breath sounds in the right upper zone. Initial imaging revealed a soft tissue lesion in the apex of the right lung, suggesting a Pancoast tumor. It also showed a lytic, expansile lesion of the T2 vertebra extending to the right second posterior rib on subsequent imaging. High serum calcium, M-spike in beta-gamma globulin region on serum electrophoresis, 50%-60% plasmacytoid cells on bone marrow aspiration, concertina collapse of the vertebral body, and pattern of neurological deficit pointed towards multiple myeloma. T2 corpectomy and mesh cage placement, C7-T4 posterior stabilization, and resection of the second rib were done. Histopathology confirmed multiple myeloma. Postoperatively, the patient was managed with radiotherapy and bortezomib. The patient had a good neurological recovery. Timely intervention is critical for disease control and leads to better recovery. Cureus 2022-02-20 /pmc/articles/PMC8942157/ /pubmed/35345749 http://dx.doi.org/10.7759/cureus.22412 Text en Copyright © 2022, Bansal et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Radiology
Bansal, Kuldeep
Singh, Sumedha
Gupta, Anuj
Chhabra, Harvinder Singh
Kalidindi, Kalyan Kumar Varma
Extraosseous Spread of Multiple Myeloma Mimicking Pancoast Tumor
title Extraosseous Spread of Multiple Myeloma Mimicking Pancoast Tumor
title_full Extraosseous Spread of Multiple Myeloma Mimicking Pancoast Tumor
title_fullStr Extraosseous Spread of Multiple Myeloma Mimicking Pancoast Tumor
title_full_unstemmed Extraosseous Spread of Multiple Myeloma Mimicking Pancoast Tumor
title_short Extraosseous Spread of Multiple Myeloma Mimicking Pancoast Tumor
title_sort extraosseous spread of multiple myeloma mimicking pancoast tumor
topic Radiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942157/
https://www.ncbi.nlm.nih.gov/pubmed/35345749
http://dx.doi.org/10.7759/cureus.22412
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