Cargando…

Characterization of intrinsically disordered regions in proteins informed by human genetic diversity

All proteomes contain both proteins and polypeptide segments that don’t form a defined three-dimensional structure yet are biologically active—called intrinsically disordered proteins and regions (IDPs and IDRs). Most of these IDPs/IDRs lack useful functional annotation limiting our understanding of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahmed, Shehab S., Rifat, Zaara T., Lohia, Ruchi, Campbell, Arthur J., Dunker, A. Keith, Rahman, M. Sohel, Iqbal, Sumaiya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942211/ https://www.ncbi.nlm.nih.gov/pubmed/35275927 http://dx.doi.org/10.1371/journal.pcbi.1009911

Ejemplares similares

MISCAST: MIssense variant to protein StruCture Analysis web SuiTe
por: Iqbal, Sumaiya, et al.
Publicado: (2020)

Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants
por: Iqbal, Sumaiya, et al.
Publicado: (2020)

Intrinsically disordered proteins play diverse roles in cell signaling
por: Bondos, Sarah E., et al.
Publicado: (2022)

On the roles of intrinsically disordered proteins and regions in cell communication and signaling
por: Bondos, Sarah E., et al.
Publicado: (2021)

Sequence specificity despite intrinsic disorder: How a disease-associated Val/Met polymorphism rearranges tertiary interactions in a long disordered protein
por: Lohia, Ruchi, et al.
Publicado: (2019)

Length-dependent prediction of protein intrinsic disorder
por: Peng, Kang, et al.
Publicado: (2006)

Classification of Intrinsically Disordered Regions and Proteins
por: van der Lee, Robin, et al.
Publicado: (2014)

Protein intrinsic disorder toolbox for comparative analysis of viral proteins
por: Goh, Gerard Kian-Meng, et al.
Publicado: (2008)

The case for intrinsically disordered proteins playing contributory roles in molecular recognition without a stable 3D structure
por: Uversky, Vladimir N., et al.
Publicado: (2013)

Archaic chaos: intrinsically disordered proteins in Archaea
por: Xue, Bin, et al.
Publicado: (2010)

Identification of Intrinsic Disorder in Complexes from the Protein Data Bank
por: Zhou, Jianhong, et al.
Publicado: (2020)

Understanding Viral Transmission Behavior via Protein Intrinsic Disorder Prediction: Coronaviruses
por: Goh, Gerard Kian-Meng, et al.
Publicado: (2012)

Distribution and cluster analysis of predicted intrinsically disordered protein Pfam domains
por: Williams, Robert W, et al.
Publicado: (2013)

Retro-MoRFs: Identifying Protein Binding Sites by Normal and Reverse Alignment and Intrinsic Disorder Prediction
por: Xue, Bin, et al.
Publicado: (2010)

Per Aspera ad Chaos: Vladimir Uversky’s Odyssey through the Strange World of Intrinsically Disordered Proteins
por: Kulkarni, Prakash, et al.
Publicado: (2023)

Prostate-associated gene 4 (PAGE4), an intrinsically disordered cancer/testis antigen, is a novel therapeutic target for prostate cancer
por: Kulkarni, Prakash, et al.
Publicado: (2016)

Entropy and Information within Intrinsically Disordered Protein Regions
por: Pritišanac, Iva, et al.
Publicado: (2019)

Prediction of Intrinsic Disorder in MERS-CoV/HCoV-EMC Supports a High Oral-Fecal Transmission
por: Goh, Gerard Kian-Meng, et al.
Publicado: (2013)

The alphabet of intrinsic disorder: I. Act like a Pro: On the abundance and roles of proline residues in intrinsically disordered proteins
por: Theillet, Francois-Xavier, et al.
Publicado: (2013)

Protein intrinsic disorder and influenza virulence: the 1918 H1N1 and H5N1 viruses
por: Goh, Gerard Kian-Meng, et al.
Publicado: (2009)

The Protein Trinity: Structure/Function Relationships That Include Intrinsic Disorder
por: Dunker, A. Keith, et al.
Publicado: (2002)

Rethinking gene regulatory networks in light of alternative splicing, intrinsically disordered protein domains, and post-translational modifications
por: Niklas, Karl J., et al.
Publicado: (2015)

The unfoldomics decade: an update on intrinsically disordered proteins
por: Dunker, A Keith, et al.
Publicado: (2008)

Analysis of the Contribution of Intrinsic Disorder in Shaping Potyvirus Genetic Diversity
por: Lafforgue, Guillaume, et al.
Publicado: (2022)

Delineation of functionally essential protein regions for 242 neurodevelopmental genes
por: Iqbal, Sumaiya, et al.
Publicado: (2022)

A creature with a hundred waggly tails: intrinsically disordered proteins in the ribosome
por: Peng, Zhenling, et al.
Publicado: (2013)

Intrinsic biophysical diversity decorrelates neuronal firing while increasing information content
por: Padmanabhan, Krishnan, et al.
Publicado: (2010)

Unfoldomics of human diseases: linking protein intrinsic disorder with diseases
por: Uversky, Vladimir N, et al.
Publicado: (2009)

A global high-density chromatin interaction network reveals functional long-range and trans-chromosomal relationships
por: Lohia, Ruchi, et al.
Publicado: (2022)

Rigidity of the Outer Shell Predicted by a Protein Intrinsic Disorder Model Sheds Light on the COVID-19 (Wuhan-2019-nCoV) Infectivity
por: Goh, Gerard Kian-Meng, et al.
Publicado: (2020)

An Information-Theoretic Perspective on Intrinsic Motivation in Reinforcement Learning: A Survey
por: Aubret, Arthur, et al.
Publicado: (2023)

A measure for intrinsic information
por: Barbosa, Leonardo S., et al.
Publicado: (2020)

Intrinsically disordered regions in the rodent hepevirus proteome
por: Shafat, Zoya, et al.
Publicado: (2022)

Contiguously hydrophobic sequences are functionally significant throughout the human exome
por: Lohia, Ruchi, et al.
Publicado: (2022)

Diversity in the intrinsic apoptosis pathway of nematodes
por: Young, Neil D., et al.
Publicado: (2020)

RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection
por: Zhao, Yang, et al.
Publicado: (2018)

A diverse intrinsic antibiotic resistome from a cave bacterium
por: Pawlowski, Andrew C., et al.
Publicado: (2016)

Prediction of Lung Function in Adolescence Using Epigenetic Aging: A Machine Learning Approach
por: Arefeen, Md Adnan, et al.
Publicado: (2020)

Sharing self-related information is associated with intrinsic functional connectivity of cortical midline brain regions
por: Meshi, Dar, et al.
Publicado: (2016)

What’s in a name? Why these proteins are intrinsically disordered: Why these proteins are intrinsically disordered
por: Dunker, A. Keith, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_98g2f53aevav0gr11qimb3qt3n