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The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity
To investigate the CGE on hair growth and to explore the mechanism that is involved in the acceleration of anagen induction, we investigated the effects of CGE studied on cell proliferation and molecular mechanism in human hair dermal papilla cells (hDPCs) and keratinocytes (HaCaT cells). Additional...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942214/ https://www.ncbi.nlm.nih.gov/pubmed/35320304 http://dx.doi.org/10.1371/journal.pone.0265532 |
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author | Ramadhani, Fatuma Jumapili Bak, Dong-Ho Kang, Seong Hee Park, Chul-hong Park, Sang hwa Chung, Byung Yeoup Bai, Hyoung-woo |
author_facet | Ramadhani, Fatuma Jumapili Bak, Dong-Ho Kang, Seong Hee Park, Chul-hong Park, Sang hwa Chung, Byung Yeoup Bai, Hyoung-woo |
author_sort | Ramadhani, Fatuma Jumapili |
collection | PubMed |
description | To investigate the CGE on hair growth and to explore the mechanism that is involved in the acceleration of anagen induction, we investigated the effects of CGE studied on cell proliferation and molecular mechanism in human hair dermal papilla cells (hDPCs) and keratinocytes (HaCaT cells). Additionally, hair growth evaluation was carried out following topical treatment of the dorsal skin of telogen C57BL/6 mice with CGE for 14 days. As result, CGE increased cell viability and ALP activity in hDPCs. Moreover, CGE increased the expression of catenin beta 1 (CTNNB1), ALP, sex-determining region Y-box 2 (SOX2), insulin-like growth factor 1 (IGF1), and vascular endothelial growth factor A (VEGFA) genes in hDPCs. CGE increased the expression of proteins such as ALP, β-catenin, and phosphorylation of glycogen synthase kinase 3β (pGSK3β), and protein kinase B (pAKT) in hDPCs. Furthermore, CGE induced the proliferation of HaCaT cells and up-regulated AKT-ERK-GSKβ-β-catenin signaling in HaCaT cells. Additionally, the anagen induction effects of CGE were confirmed on the telogen-anagen transition mice model. these findings demonstrated that CGE promoted the entering the growth phase of hair follicle via activation of β-catenin signaling pathways in vivo. Thus, this study suggests that CGE might be a potential therapeutic reagent for hair growth. |
format | Online Article Text |
id | pubmed-8942214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-89422142022-03-24 The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity Ramadhani, Fatuma Jumapili Bak, Dong-Ho Kang, Seong Hee Park, Chul-hong Park, Sang hwa Chung, Byung Yeoup Bai, Hyoung-woo PLoS One Research Article To investigate the CGE on hair growth and to explore the mechanism that is involved in the acceleration of anagen induction, we investigated the effects of CGE studied on cell proliferation and molecular mechanism in human hair dermal papilla cells (hDPCs) and keratinocytes (HaCaT cells). Additionally, hair growth evaluation was carried out following topical treatment of the dorsal skin of telogen C57BL/6 mice with CGE for 14 days. As result, CGE increased cell viability and ALP activity in hDPCs. Moreover, CGE increased the expression of catenin beta 1 (CTNNB1), ALP, sex-determining region Y-box 2 (SOX2), insulin-like growth factor 1 (IGF1), and vascular endothelial growth factor A (VEGFA) genes in hDPCs. CGE increased the expression of proteins such as ALP, β-catenin, and phosphorylation of glycogen synthase kinase 3β (pGSK3β), and protein kinase B (pAKT) in hDPCs. Furthermore, CGE induced the proliferation of HaCaT cells and up-regulated AKT-ERK-GSKβ-β-catenin signaling in HaCaT cells. Additionally, the anagen induction effects of CGE were confirmed on the telogen-anagen transition mice model. these findings demonstrated that CGE promoted the entering the growth phase of hair follicle via activation of β-catenin signaling pathways in vivo. Thus, this study suggests that CGE might be a potential therapeutic reagent for hair growth. Public Library of Science 2022-03-23 /pmc/articles/PMC8942214/ /pubmed/35320304 http://dx.doi.org/10.1371/journal.pone.0265532 Text en © 2022 Ramadhani et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Ramadhani, Fatuma Jumapili Bak, Dong-Ho Kang, Seong Hee Park, Chul-hong Park, Sang hwa Chung, Byung Yeoup Bai, Hyoung-woo The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity |
title | The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity |
title_full | The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity |
title_fullStr | The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity |
title_full_unstemmed | The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity |
title_short | The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity |
title_sort | effects of centipedegrass extract on hair growth via promotion of anagen inductive activity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942214/ https://www.ncbi.nlm.nih.gov/pubmed/35320304 http://dx.doi.org/10.1371/journal.pone.0265532 |
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