Cargando…

The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity

To investigate the CGE on hair growth and to explore the mechanism that is involved in the acceleration of anagen induction, we investigated the effects of CGE studied on cell proliferation and molecular mechanism in human hair dermal papilla cells (hDPCs) and keratinocytes (HaCaT cells). Additional...

Descripción completa

Detalles Bibliográficos
Autores principales: Ramadhani, Fatuma Jumapili, Bak, Dong-Ho, Kang, Seong Hee, Park, Chul-hong, Park, Sang hwa, Chung, Byung Yeoup, Bai, Hyoung-woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942214/
https://www.ncbi.nlm.nih.gov/pubmed/35320304
http://dx.doi.org/10.1371/journal.pone.0265532
_version_ 1784673258370498560
author Ramadhani, Fatuma Jumapili
Bak, Dong-Ho
Kang, Seong Hee
Park, Chul-hong
Park, Sang hwa
Chung, Byung Yeoup
Bai, Hyoung-woo
author_facet Ramadhani, Fatuma Jumapili
Bak, Dong-Ho
Kang, Seong Hee
Park, Chul-hong
Park, Sang hwa
Chung, Byung Yeoup
Bai, Hyoung-woo
author_sort Ramadhani, Fatuma Jumapili
collection PubMed
description To investigate the CGE on hair growth and to explore the mechanism that is involved in the acceleration of anagen induction, we investigated the effects of CGE studied on cell proliferation and molecular mechanism in human hair dermal papilla cells (hDPCs) and keratinocytes (HaCaT cells). Additionally, hair growth evaluation was carried out following topical treatment of the dorsal skin of telogen C57BL/6 mice with CGE for 14 days. As result, CGE increased cell viability and ALP activity in hDPCs. Moreover, CGE increased the expression of catenin beta 1 (CTNNB1), ALP, sex-determining region Y-box 2 (SOX2), insulin-like growth factor 1 (IGF1), and vascular endothelial growth factor A (VEGFA) genes in hDPCs. CGE increased the expression of proteins such as ALP, β-catenin, and phosphorylation of glycogen synthase kinase 3β (pGSK3β), and protein kinase B (pAKT) in hDPCs. Furthermore, CGE induced the proliferation of HaCaT cells and up-regulated AKT-ERK-GSKβ-β-catenin signaling in HaCaT cells. Additionally, the anagen induction effects of CGE were confirmed on the telogen-anagen transition mice model. these findings demonstrated that CGE promoted the entering the growth phase of hair follicle via activation of β-catenin signaling pathways in vivo. Thus, this study suggests that CGE might be a potential therapeutic reagent for hair growth.
format Online
Article
Text
id pubmed-8942214
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-89422142022-03-24 The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity Ramadhani, Fatuma Jumapili Bak, Dong-Ho Kang, Seong Hee Park, Chul-hong Park, Sang hwa Chung, Byung Yeoup Bai, Hyoung-woo PLoS One Research Article To investigate the CGE on hair growth and to explore the mechanism that is involved in the acceleration of anagen induction, we investigated the effects of CGE studied on cell proliferation and molecular mechanism in human hair dermal papilla cells (hDPCs) and keratinocytes (HaCaT cells). Additionally, hair growth evaluation was carried out following topical treatment of the dorsal skin of telogen C57BL/6 mice with CGE for 14 days. As result, CGE increased cell viability and ALP activity in hDPCs. Moreover, CGE increased the expression of catenin beta 1 (CTNNB1), ALP, sex-determining region Y-box 2 (SOX2), insulin-like growth factor 1 (IGF1), and vascular endothelial growth factor A (VEGFA) genes in hDPCs. CGE increased the expression of proteins such as ALP, β-catenin, and phosphorylation of glycogen synthase kinase 3β (pGSK3β), and protein kinase B (pAKT) in hDPCs. Furthermore, CGE induced the proliferation of HaCaT cells and up-regulated AKT-ERK-GSKβ-β-catenin signaling in HaCaT cells. Additionally, the anagen induction effects of CGE were confirmed on the telogen-anagen transition mice model. these findings demonstrated that CGE promoted the entering the growth phase of hair follicle via activation of β-catenin signaling pathways in vivo. Thus, this study suggests that CGE might be a potential therapeutic reagent for hair growth. Public Library of Science 2022-03-23 /pmc/articles/PMC8942214/ /pubmed/35320304 http://dx.doi.org/10.1371/journal.pone.0265532 Text en © 2022 Ramadhani et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ramadhani, Fatuma Jumapili
Bak, Dong-Ho
Kang, Seong Hee
Park, Chul-hong
Park, Sang hwa
Chung, Byung Yeoup
Bai, Hyoung-woo
The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity
title The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity
title_full The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity
title_fullStr The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity
title_full_unstemmed The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity
title_short The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity
title_sort effects of centipedegrass extract on hair growth via promotion of anagen inductive activity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942214/
https://www.ncbi.nlm.nih.gov/pubmed/35320304
http://dx.doi.org/10.1371/journal.pone.0265532
work_keys_str_mv AT ramadhanifatumajumapili theeffectsofcentipedegrassextractonhairgrowthviapromotionofanageninductiveactivity
AT bakdongho theeffectsofcentipedegrassextractonhairgrowthviapromotionofanageninductiveactivity
AT kangseonghee theeffectsofcentipedegrassextractonhairgrowthviapromotionofanageninductiveactivity
AT parkchulhong theeffectsofcentipedegrassextractonhairgrowthviapromotionofanageninductiveactivity
AT parksanghwa theeffectsofcentipedegrassextractonhairgrowthviapromotionofanageninductiveactivity
AT chungbyungyeoup theeffectsofcentipedegrassextractonhairgrowthviapromotionofanageninductiveactivity
AT baihyoungwoo theeffectsofcentipedegrassextractonhairgrowthviapromotionofanageninductiveactivity
AT ramadhanifatumajumapili effectsofcentipedegrassextractonhairgrowthviapromotionofanageninductiveactivity
AT bakdongho effectsofcentipedegrassextractonhairgrowthviapromotionofanageninductiveactivity
AT kangseonghee effectsofcentipedegrassextractonhairgrowthviapromotionofanageninductiveactivity
AT parkchulhong effectsofcentipedegrassextractonhairgrowthviapromotionofanageninductiveactivity
AT parksanghwa effectsofcentipedegrassextractonhairgrowthviapromotionofanageninductiveactivity
AT chungbyungyeoup effectsofcentipedegrassextractonhairgrowthviapromotionofanageninductiveactivity
AT baihyoungwoo effectsofcentipedegrassextractonhairgrowthviapromotionofanageninductiveactivity