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GaitSmart motion analysis compared to commonly used function outcome measures in the IMI-APPROACH knee osteoarthritis cohort

BACKGROUND: There are multiple measures for assessment of physical function in knee osteoarthritis (OA), but each has its strengths and limitations. The GaitSmart® system, which uses inertial measurement units (IMUs), might be a user-friendly and objective method to assess function. This study evalu...

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Autores principales: van Helvoort, Eefje M., Hodgins, D., Mastbergen, Simon C., Marijnissen, Anne C. A., Kloppenburg, M., Blanco, Fransisco J., Haugen, Ida K., Berenbaum, F., Lafeber, Floris P. J. G., Welsing, Paco M. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942249/
https://www.ncbi.nlm.nih.gov/pubmed/35320321
http://dx.doi.org/10.1371/journal.pone.0265883
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author van Helvoort, Eefje M.
Hodgins, D.
Mastbergen, Simon C.
Marijnissen, Anne C. A.
Kloppenburg, M.
Blanco, Fransisco J.
Haugen, Ida K.
Berenbaum, F.
Lafeber, Floris P. J. G.
Welsing, Paco M. J.
author_facet van Helvoort, Eefje M.
Hodgins, D.
Mastbergen, Simon C.
Marijnissen, Anne C. A.
Kloppenburg, M.
Blanco, Fransisco J.
Haugen, Ida K.
Berenbaum, F.
Lafeber, Floris P. J. G.
Welsing, Paco M. J.
author_sort van Helvoort, Eefje M.
collection PubMed
description BACKGROUND: There are multiple measures for assessment of physical function in knee osteoarthritis (OA), but each has its strengths and limitations. The GaitSmart® system, which uses inertial measurement units (IMUs), might be a user-friendly and objective method to assess function. This study evaluates the validity and responsiveness of GaitSmart® motion analysis as a function measurement in knee OA and compares this to Knee Injury and Osteoarthritis Outcome Score (KOOS), Short Form 36 Health Survey (SF-36), 30s chair stand test, and 40m self-paced walk test. METHODS: The 2-year Innovative Medicines Initiative—Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) knee OA cohort was conducted between January 2018 and April 2021. For this study, available baseline and 6 months follow-up data (n = 262) was used. Principal component analysis was used to investigate whether above mentioned function instruments could represent one or more function domains. Subsequently, linear regression was used to explore the association between GaitSmart® parameters and those function domains. In addition, standardized response means, effect sizes and t-tests were calculated to evaluate the ability of GaitSmart® to differentiate between good and poor general health (based on SF-36). Lastly, the responsiveness of GaitSmart® to detect changes in function was determined. RESULTS: KOOS, SF-36, 30s chair test and 40m self-paced walk test were first combined into one function domain (total function). Thereafter, two function domains were substracted related to either performance based (objective function) or self-reported (subjective function) function. Linear regression resulted in the highest R(2) for the total function domain: 0.314 (R(2) for objective and subjective function were 0.252 and 0.142, respectively.). Furthermore, GaitSmart® was able to distinguish a difference in general health status, and is responsive to changes in the different aspects of objective function (Standardized response mean (SRMs) up to 0.74). CONCLUSION: GaitSmart® analysis can reflect performance based and self-reported function and may be of value in the evaluation of function in knee OA. Future studies are warranted to validate whether GaitSmart® can be used as clinical outcome measure in OA research and clinical practice.
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spelling pubmed-89422492022-03-24 GaitSmart motion analysis compared to commonly used function outcome measures in the IMI-APPROACH knee osteoarthritis cohort van Helvoort, Eefje M. Hodgins, D. Mastbergen, Simon C. Marijnissen, Anne C. A. Kloppenburg, M. Blanco, Fransisco J. Haugen, Ida K. Berenbaum, F. Lafeber, Floris P. J. G. Welsing, Paco M. J. PLoS One Research Article BACKGROUND: There are multiple measures for assessment of physical function in knee osteoarthritis (OA), but each has its strengths and limitations. The GaitSmart® system, which uses inertial measurement units (IMUs), might be a user-friendly and objective method to assess function. This study evaluates the validity and responsiveness of GaitSmart® motion analysis as a function measurement in knee OA and compares this to Knee Injury and Osteoarthritis Outcome Score (KOOS), Short Form 36 Health Survey (SF-36), 30s chair stand test, and 40m self-paced walk test. METHODS: The 2-year Innovative Medicines Initiative—Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) knee OA cohort was conducted between January 2018 and April 2021. For this study, available baseline and 6 months follow-up data (n = 262) was used. Principal component analysis was used to investigate whether above mentioned function instruments could represent one or more function domains. Subsequently, linear regression was used to explore the association between GaitSmart® parameters and those function domains. In addition, standardized response means, effect sizes and t-tests were calculated to evaluate the ability of GaitSmart® to differentiate between good and poor general health (based on SF-36). Lastly, the responsiveness of GaitSmart® to detect changes in function was determined. RESULTS: KOOS, SF-36, 30s chair test and 40m self-paced walk test were first combined into one function domain (total function). Thereafter, two function domains were substracted related to either performance based (objective function) or self-reported (subjective function) function. Linear regression resulted in the highest R(2) for the total function domain: 0.314 (R(2) for objective and subjective function were 0.252 and 0.142, respectively.). Furthermore, GaitSmart® was able to distinguish a difference in general health status, and is responsive to changes in the different aspects of objective function (Standardized response mean (SRMs) up to 0.74). CONCLUSION: GaitSmart® analysis can reflect performance based and self-reported function and may be of value in the evaluation of function in knee OA. Future studies are warranted to validate whether GaitSmart® can be used as clinical outcome measure in OA research and clinical practice. Public Library of Science 2022-03-23 /pmc/articles/PMC8942249/ /pubmed/35320321 http://dx.doi.org/10.1371/journal.pone.0265883 Text en © 2022 van Helvoort et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
van Helvoort, Eefje M.
Hodgins, D.
Mastbergen, Simon C.
Marijnissen, Anne C. A.
Kloppenburg, M.
Blanco, Fransisco J.
Haugen, Ida K.
Berenbaum, F.
Lafeber, Floris P. J. G.
Welsing, Paco M. J.
GaitSmart motion analysis compared to commonly used function outcome measures in the IMI-APPROACH knee osteoarthritis cohort
title GaitSmart motion analysis compared to commonly used function outcome measures in the IMI-APPROACH knee osteoarthritis cohort
title_full GaitSmart motion analysis compared to commonly used function outcome measures in the IMI-APPROACH knee osteoarthritis cohort
title_fullStr GaitSmart motion analysis compared to commonly used function outcome measures in the IMI-APPROACH knee osteoarthritis cohort
title_full_unstemmed GaitSmart motion analysis compared to commonly used function outcome measures in the IMI-APPROACH knee osteoarthritis cohort
title_short GaitSmart motion analysis compared to commonly used function outcome measures in the IMI-APPROACH knee osteoarthritis cohort
title_sort gaitsmart motion analysis compared to commonly used function outcome measures in the imi-approach knee osteoarthritis cohort
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942249/
https://www.ncbi.nlm.nih.gov/pubmed/35320321
http://dx.doi.org/10.1371/journal.pone.0265883
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