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Wearable plasmonic paper–based microfluidics for continuous sweat analysis

Wearable sweat sensors have the potential to provide clinically meaningful information associated with the health and disease states of individuals. Current sensors mainly rely on enzymes and antibodies as biorecognition elements to achieve specific quantification of metabolite and stress biomarkers...

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Detalles Bibliográficos
Autores principales: Mogera, Umesha, Guo, Heng, Namkoong, Myeong, Rahman, Md Saifur, Nguyen, Tan, Tian, Limei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942375/
https://www.ncbi.nlm.nih.gov/pubmed/35319971
http://dx.doi.org/10.1126/sciadv.abn1736
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author Mogera, Umesha
Guo, Heng
Namkoong, Myeong
Rahman, Md Saifur
Nguyen, Tan
Tian, Limei
author_facet Mogera, Umesha
Guo, Heng
Namkoong, Myeong
Rahman, Md Saifur
Nguyen, Tan
Tian, Limei
author_sort Mogera, Umesha
collection PubMed
description Wearable sweat sensors have the potential to provide clinically meaningful information associated with the health and disease states of individuals. Current sensors mainly rely on enzymes and antibodies as biorecognition elements to achieve specific quantification of metabolite and stress biomarkers in sweat. However, enzymes and antibodies are prone to degrade over time, compromising the sensor performance. Here, we introduce a wearable plasmonic paper–based microfluidic system for continuous and simultaneous quantitative analysis of sweat loss, sweat rate, and metabolites in sweat. Plasmonic sensors based on label-free surface-enhanced Raman spectroscopy (SERS) can provide chemical “fingerprint” information for analyte identification. We demonstrate the sensitive detection and quantification of uric acid in sweat at physiological and pathological concentrations. The well-defined flow characteristics of paper microfluidic devices enable accurate quantification of sweat loss and sweat rate. The wearable plasmonic device is soft, flexible, and stretchable, which can robustly interface with the skin without inducing chemical or physical irritation.
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spelling pubmed-89423752022-04-04 Wearable plasmonic paper–based microfluidics for continuous sweat analysis Mogera, Umesha Guo, Heng Namkoong, Myeong Rahman, Md Saifur Nguyen, Tan Tian, Limei Sci Adv Physical and Materials Sciences Wearable sweat sensors have the potential to provide clinically meaningful information associated with the health and disease states of individuals. Current sensors mainly rely on enzymes and antibodies as biorecognition elements to achieve specific quantification of metabolite and stress biomarkers in sweat. However, enzymes and antibodies are prone to degrade over time, compromising the sensor performance. Here, we introduce a wearable plasmonic paper–based microfluidic system for continuous and simultaneous quantitative analysis of sweat loss, sweat rate, and metabolites in sweat. Plasmonic sensors based on label-free surface-enhanced Raman spectroscopy (SERS) can provide chemical “fingerprint” information for analyte identification. We demonstrate the sensitive detection and quantification of uric acid in sweat at physiological and pathological concentrations. The well-defined flow characteristics of paper microfluidic devices enable accurate quantification of sweat loss and sweat rate. The wearable plasmonic device is soft, flexible, and stretchable, which can robustly interface with the skin without inducing chemical or physical irritation. American Association for the Advancement of Science 2022-03-23 /pmc/articles/PMC8942375/ /pubmed/35319971 http://dx.doi.org/10.1126/sciadv.abn1736 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Physical and Materials Sciences
Mogera, Umesha
Guo, Heng
Namkoong, Myeong
Rahman, Md Saifur
Nguyen, Tan
Tian, Limei
Wearable plasmonic paper–based microfluidics for continuous sweat analysis
title Wearable plasmonic paper–based microfluidics for continuous sweat analysis
title_full Wearable plasmonic paper–based microfluidics for continuous sweat analysis
title_fullStr Wearable plasmonic paper–based microfluidics for continuous sweat analysis
title_full_unstemmed Wearable plasmonic paper–based microfluidics for continuous sweat analysis
title_short Wearable plasmonic paper–based microfluidics for continuous sweat analysis
title_sort wearable plasmonic paper–based microfluidics for continuous sweat analysis
topic Physical and Materials Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942375/
https://www.ncbi.nlm.nih.gov/pubmed/35319971
http://dx.doi.org/10.1126/sciadv.abn1736
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