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Wearable plasmonic paper–based microfluidics for continuous sweat analysis
Wearable sweat sensors have the potential to provide clinically meaningful information associated with the health and disease states of individuals. Current sensors mainly rely on enzymes and antibodies as biorecognition elements to achieve specific quantification of metabolite and stress biomarkers...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942375/ https://www.ncbi.nlm.nih.gov/pubmed/35319971 http://dx.doi.org/10.1126/sciadv.abn1736 |
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author | Mogera, Umesha Guo, Heng Namkoong, Myeong Rahman, Md Saifur Nguyen, Tan Tian, Limei |
author_facet | Mogera, Umesha Guo, Heng Namkoong, Myeong Rahman, Md Saifur Nguyen, Tan Tian, Limei |
author_sort | Mogera, Umesha |
collection | PubMed |
description | Wearable sweat sensors have the potential to provide clinically meaningful information associated with the health and disease states of individuals. Current sensors mainly rely on enzymes and antibodies as biorecognition elements to achieve specific quantification of metabolite and stress biomarkers in sweat. However, enzymes and antibodies are prone to degrade over time, compromising the sensor performance. Here, we introduce a wearable plasmonic paper–based microfluidic system for continuous and simultaneous quantitative analysis of sweat loss, sweat rate, and metabolites in sweat. Plasmonic sensors based on label-free surface-enhanced Raman spectroscopy (SERS) can provide chemical “fingerprint” information for analyte identification. We demonstrate the sensitive detection and quantification of uric acid in sweat at physiological and pathological concentrations. The well-defined flow characteristics of paper microfluidic devices enable accurate quantification of sweat loss and sweat rate. The wearable plasmonic device is soft, flexible, and stretchable, which can robustly interface with the skin without inducing chemical or physical irritation. |
format | Online Article Text |
id | pubmed-8942375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-89423752022-04-04 Wearable plasmonic paper–based microfluidics for continuous sweat analysis Mogera, Umesha Guo, Heng Namkoong, Myeong Rahman, Md Saifur Nguyen, Tan Tian, Limei Sci Adv Physical and Materials Sciences Wearable sweat sensors have the potential to provide clinically meaningful information associated with the health and disease states of individuals. Current sensors mainly rely on enzymes and antibodies as biorecognition elements to achieve specific quantification of metabolite and stress biomarkers in sweat. However, enzymes and antibodies are prone to degrade over time, compromising the sensor performance. Here, we introduce a wearable plasmonic paper–based microfluidic system for continuous and simultaneous quantitative analysis of sweat loss, sweat rate, and metabolites in sweat. Plasmonic sensors based on label-free surface-enhanced Raman spectroscopy (SERS) can provide chemical “fingerprint” information for analyte identification. We demonstrate the sensitive detection and quantification of uric acid in sweat at physiological and pathological concentrations. The well-defined flow characteristics of paper microfluidic devices enable accurate quantification of sweat loss and sweat rate. The wearable plasmonic device is soft, flexible, and stretchable, which can robustly interface with the skin without inducing chemical or physical irritation. American Association for the Advancement of Science 2022-03-23 /pmc/articles/PMC8942375/ /pubmed/35319971 http://dx.doi.org/10.1126/sciadv.abn1736 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Physical and Materials Sciences Mogera, Umesha Guo, Heng Namkoong, Myeong Rahman, Md Saifur Nguyen, Tan Tian, Limei Wearable plasmonic paper–based microfluidics for continuous sweat analysis |
title | Wearable plasmonic paper–based microfluidics for continuous sweat analysis |
title_full | Wearable plasmonic paper–based microfluidics for continuous sweat analysis |
title_fullStr | Wearable plasmonic paper–based microfluidics for continuous sweat analysis |
title_full_unstemmed | Wearable plasmonic paper–based microfluidics for continuous sweat analysis |
title_short | Wearable plasmonic paper–based microfluidics for continuous sweat analysis |
title_sort | wearable plasmonic paper–based microfluidics for continuous sweat analysis |
topic | Physical and Materials Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942375/ https://www.ncbi.nlm.nih.gov/pubmed/35319971 http://dx.doi.org/10.1126/sciadv.abn1736 |
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