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GPX1 knockout, not catalase knockout, causes accelerated abnormal optical aberrations and cataract in the aging lens

PURPOSE: Glutathione peroxidase 1 (GPX1) and catalase are expressed in the lens epithelial cells and cortical fiber cells, where they detoxify H2O2 to reduce oxidative stress, which is a major cause for cataractogenesis. We sought to find out, between these two enzymes, which is critical for transpa...

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Detalles Bibliográficos
Autores principales: Varadaraj, Kulandaiappan, Gao, Junyuan, Mathias, Richard T., Kumari, S. Sindhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942455/
https://www.ncbi.nlm.nih.gov/pubmed/35400989

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