Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening

Trypanothione synthetase (TryS) catalyses the synthesis of N(1),N(8)-bis(glutathionyl)spermidine (trypanothione), which is the main low molecular mass thiol supporting several redox functions in trypanosomatids. TryS attracts attention as molecular target for drug development against pathogens causi...

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Detalles Bibliográficos
Autores principales: Benítez, Diego, Franco, Jaime, Sardi, Florencia, Leyva, Alejandro, Durán, Rosario, Choi, Gahee, Yang, Gyongseon, Kim, Taehee, Kim, Namyoul, Heo, Jinyeong, Kim, Kideok, Lee, Honggun, Choi, Inhee, Radu, Constantin, Shum, David, No, Joo Hwan, Comini, Marcelo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942522/
https://www.ncbi.nlm.nih.gov/pubmed/35306933
http://dx.doi.org/10.1080/14756366.2022.2045590

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