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Design and synthesis of benzodiazepines as brain penetrating PARP-1 inhibitors

The poly (ADP-ribose) polymerase (PARP) inhibitors play a crucial role in cancer therapy. However, most approved PARP inhibitors cannot cross the blood-brain barrier, thus limiting their application in the central nervous system. Here, 55 benzodiazepines were designed and synthesised to screen brain...

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Detalles Bibliográficos
Autores principales:	Yu, Jiang, Gou, Wenfeng, Shang, Haihua, Cui, Yating, Sun, Xiao, Luo, Lingling, Hou, Wenbin, Sun, Tiemin, Li, Yiliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942544/ https://www.ncbi.nlm.nih.gov/pubmed/35317687 http://dx.doi.org/10.1080/14756366.2022.2053524

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