Cargando…

Hyperechoic pancreas on ultrasonography: an analysis of its severity and clinical implications

PURPOSE: This study investigated risk factors for hyperechoic pancreas (HP) on ultrasonography (US) according to HP severity. METHODS: Between December 2008 and February 2014, 1,459 subjects who underwent abdominal US as part of health examinations were retrospectively included. Two radiologists ass...

Descripción completa

Detalles Bibliográficos
Autores principales: Oh, Hyunji, Park, Hyun Jeong, Oh, Jiyun, Lee, Eun Sun, Park, Sung Bin, Cha, Min Jae, Ahn, Soohyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Ultrasound in Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942727/
https://www.ncbi.nlm.nih.gov/pubmed/34743485
http://dx.doi.org/10.14366/usg.21099
_version_ 1784673365802352640
author Oh, Hyunji
Park, Hyun Jeong
Oh, Jiyun
Lee, Eun Sun
Park, Sung Bin
Cha, Min Jae
Ahn, Soohyun
author_facet Oh, Hyunji
Park, Hyun Jeong
Oh, Jiyun
Lee, Eun Sun
Park, Sung Bin
Cha, Min Jae
Ahn, Soohyun
author_sort Oh, Hyunji
collection PubMed
description PURPOSE: This study investigated risk factors for hyperechoic pancreas (HP) on ultrasonography (US) according to HP severity. METHODS: Between December 2008 and February 2014, 1,459 subjects who underwent abdominal US as part of health examinations were retrospectively included. Two radiologists assessed and categorized the severity of HP as normal, mild, moderate, and severe. Subjects were allocated to two groups as follows: fatty pancreas 1 (FP1; mild to severe HP) and fatty pancreas 2 (FP2; moderate to severe HP). Clinico-metabolic parameters such as the body mass index and blood test profile of subjects with normoglycemia and prediabetes/diabetes were compared (normal vs. FP1; normal or mild HP vs. FP2). Logistic regression analysis was used to evaluate the associations between HP, nonalcoholic fatty liver disease (NAFLD), and diabetes/prediabetes with adjustment for clinico-metabolic parameters. RESULTS: Of the 1,459 subjects, 71.2% and 40.4% showed HP and NAFLD on US, respectively. Normoglycemia and prediabetes/diabetes were present in 74.3% and 25.7% of subjects, respectively. Univariable analysis revealed that all the clinico-metabolic parameters were significantly associated with HP (all P<0.05). In the adjusted multivariable analysis, prediabetes/diabetes, NAFLD, age, and body mass index were significantly associated with HP with the FP1 and FP2 criteria. The independent factor with the strongest association with HP was NAFLD using the FP1 criterion (odds ratio [OR], 7.93; P<0.001) and prediabetes/diabetes using the FP2 criterion (OR, 6.96; P<0.001). CONCLUSION: NAFLD and prediabetes/diabetes were associated with US-diagnosed HP. Moderate to severe HP was a better predictor of prediabetes/diabetes, suggesting that evaluating HP severity may be useful in clinical practice.
format Online
Article
Text
id pubmed-8942727
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Korean Society of Ultrasound in Medicine
record_format MEDLINE/PubMed
spelling pubmed-89427272022-04-01 Hyperechoic pancreas on ultrasonography: an analysis of its severity and clinical implications Oh, Hyunji Park, Hyun Jeong Oh, Jiyun Lee, Eun Sun Park, Sung Bin Cha, Min Jae Ahn, Soohyun Ultrasonography Original Article PURPOSE: This study investigated risk factors for hyperechoic pancreas (HP) on ultrasonography (US) according to HP severity. METHODS: Between December 2008 and February 2014, 1,459 subjects who underwent abdominal US as part of health examinations were retrospectively included. Two radiologists assessed and categorized the severity of HP as normal, mild, moderate, and severe. Subjects were allocated to two groups as follows: fatty pancreas 1 (FP1; mild to severe HP) and fatty pancreas 2 (FP2; moderate to severe HP). Clinico-metabolic parameters such as the body mass index and blood test profile of subjects with normoglycemia and prediabetes/diabetes were compared (normal vs. FP1; normal or mild HP vs. FP2). Logistic regression analysis was used to evaluate the associations between HP, nonalcoholic fatty liver disease (NAFLD), and diabetes/prediabetes with adjustment for clinico-metabolic parameters. RESULTS: Of the 1,459 subjects, 71.2% and 40.4% showed HP and NAFLD on US, respectively. Normoglycemia and prediabetes/diabetes were present in 74.3% and 25.7% of subjects, respectively. Univariable analysis revealed that all the clinico-metabolic parameters were significantly associated with HP (all P<0.05). In the adjusted multivariable analysis, prediabetes/diabetes, NAFLD, age, and body mass index were significantly associated with HP with the FP1 and FP2 criteria. The independent factor with the strongest association with HP was NAFLD using the FP1 criterion (odds ratio [OR], 7.93; P<0.001) and prediabetes/diabetes using the FP2 criterion (OR, 6.96; P<0.001). CONCLUSION: NAFLD and prediabetes/diabetes were associated with US-diagnosed HP. Moderate to severe HP was a better predictor of prediabetes/diabetes, suggesting that evaluating HP severity may be useful in clinical practice. Korean Society of Ultrasound in Medicine 2022-04 2021-09-30 /pmc/articles/PMC8942727/ /pubmed/34743485 http://dx.doi.org/10.14366/usg.21099 Text en Copyright © 2022 Korean Society of Ultrasound in Medicine (KSUM) https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Oh, Hyunji
Park, Hyun Jeong
Oh, Jiyun
Lee, Eun Sun
Park, Sung Bin
Cha, Min Jae
Ahn, Soohyun
Hyperechoic pancreas on ultrasonography: an analysis of its severity and clinical implications
title Hyperechoic pancreas on ultrasonography: an analysis of its severity and clinical implications
title_full Hyperechoic pancreas on ultrasonography: an analysis of its severity and clinical implications
title_fullStr Hyperechoic pancreas on ultrasonography: an analysis of its severity and clinical implications
title_full_unstemmed Hyperechoic pancreas on ultrasonography: an analysis of its severity and clinical implications
title_short Hyperechoic pancreas on ultrasonography: an analysis of its severity and clinical implications
title_sort hyperechoic pancreas on ultrasonography: an analysis of its severity and clinical implications
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942727/
https://www.ncbi.nlm.nih.gov/pubmed/34743485
http://dx.doi.org/10.14366/usg.21099
work_keys_str_mv AT ohhyunji hyperechoicpancreasonultrasonographyananalysisofitsseverityandclinicalimplications
AT parkhyunjeong hyperechoicpancreasonultrasonographyananalysisofitsseverityandclinicalimplications
AT ohjiyun hyperechoicpancreasonultrasonographyananalysisofitsseverityandclinicalimplications
AT leeeunsun hyperechoicpancreasonultrasonographyananalysisofitsseverityandclinicalimplications
AT parksungbin hyperechoicpancreasonultrasonographyananalysisofitsseverityandclinicalimplications
AT chaminjae hyperechoicpancreasonultrasonographyananalysisofitsseverityandclinicalimplications
AT ahnsoohyun hyperechoicpancreasonultrasonographyananalysisofitsseverityandclinicalimplications