Role of medical comorbidity in the association between psychiatric disorders and mortality among patients with COVID-19

We examined whether excess chronic medical comorbidity mediated excess COVID-19 inpatient mortality among people with mental disorders in the early phase of the pandemic, a question with important implications for public health and clinical decision-making. Using records of 2599 COVID-19 hospitalize...

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Detalles Bibliográficos
Autores principales: Martínez-Alés, Gonzalo, Fernández-Jiménez, Eduardo, Mediavilla, Roberto, Quintana-Díaz, Manuel, Louzao, Iker, Cebolla, Susana, Muñoz-Sanjosé, Ainoa, Bayón, Carmen, Susser, Ezra S., Bravo-Ortiz, María Fe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942759/
https://www.ncbi.nlm.nih.gov/pubmed/35322285
http://dx.doi.org/10.1007/s00127-022-02271-5
Descripción
Sumario:We examined whether excess chronic medical comorbidity mediated excess COVID-19 inpatient mortality among people with mental disorders in the early phase of the pandemic, a question with important implications for public health and clinical decision-making. Using records of 2599 COVID-19 hospitalized patients, we conducted a formal causal mediation analysis to estimate the extent to which chronic comorbidity mediates the association between mental disorders and COVID-19 mortality. The Odds Ratio (95% CI) for Natural Indirect Effect and Controlled Direct Effect were 1.07(1.02, 1.14) and 1.40 (1.00, 1.95), respectively, suggesting that a large proportion of excess COVID-19 mortality among people with mental disorders may be explained by factors other than comorbidity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00127-022-02271-5.

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