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Altered Expression of Brain-specific Autism-Associated miRNAs in the Han Chinese Population

Autism is a complex neurodevelopmental disorder. However, its etiology is still unknown. MicroRNAs (miRNAs) are key post-transcriptional regulators. They play an important role in neurodevelopment and brain functions and may be involved in the pathogenesis of autism. Previous studies indicated alter...

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Autores principales: Wang, Ziqi, Lu, Tianlan, Li, Xianjing, Jiang, Miaomiao, Jia, Meixiang, Liu, Jing, Zhang, Dai, Li, Jun, Wang, Lifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942769/
https://www.ncbi.nlm.nih.gov/pubmed/35342389
http://dx.doi.org/10.3389/fgene.2022.865881
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author Wang, Ziqi
Lu, Tianlan
Li, Xianjing
Jiang, Miaomiao
Jia, Meixiang
Liu, Jing
Zhang, Dai
Li, Jun
Wang, Lifang
author_facet Wang, Ziqi
Lu, Tianlan
Li, Xianjing
Jiang, Miaomiao
Jia, Meixiang
Liu, Jing
Zhang, Dai
Li, Jun
Wang, Lifang
author_sort Wang, Ziqi
collection PubMed
description Autism is a complex neurodevelopmental disorder. However, its etiology is still unknown. MicroRNAs (miRNAs) are key post-transcriptional regulators. They play an important role in neurodevelopment and brain functions and may be involved in the pathogenesis of autism. Previous studies indicated altered expression of miRNAs in patients with autism. However, the findings were not consistent, and further explorations were needed. This study aimed to investigate whether miRNAs were dysregulated in autism. We examined the expression of 30 brain-specific autism-associated miRNAs in 110 patients with autism and 113 controls in the Han Chinese population using quantitative reverse transcription–polymerase chain reaction. The results demonstrated that 10 miRNAs (hsa-miR-191-5p, hsa-miR-151a-3p, hsa-miR-139-5p, hsa-miR-181a-5p, hsa-miR-432-5p, hsa-miR-181b-5p, hsa-miR-195-5p, hsa-miR-328-3p, hsa-miR-106a-5p, and hsa-miR-484) were significantly differentially expressed (false discovery rate <0.05). All of them were up-regulated in patients with autism compared with controls. The targets of these miRNAs were enriched for genes and pathways related to neurodevelopment, brain functions and autism. These findings suggested the participation of these 10 miRNAs in the pathogenesis of autism in the Han Chinese population.
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spelling pubmed-89427692022-03-25 Altered Expression of Brain-specific Autism-Associated miRNAs in the Han Chinese Population Wang, Ziqi Lu, Tianlan Li, Xianjing Jiang, Miaomiao Jia, Meixiang Liu, Jing Zhang, Dai Li, Jun Wang, Lifang Front Genet Genetics Autism is a complex neurodevelopmental disorder. However, its etiology is still unknown. MicroRNAs (miRNAs) are key post-transcriptional regulators. They play an important role in neurodevelopment and brain functions and may be involved in the pathogenesis of autism. Previous studies indicated altered expression of miRNAs in patients with autism. However, the findings were not consistent, and further explorations were needed. This study aimed to investigate whether miRNAs were dysregulated in autism. We examined the expression of 30 brain-specific autism-associated miRNAs in 110 patients with autism and 113 controls in the Han Chinese population using quantitative reverse transcription–polymerase chain reaction. The results demonstrated that 10 miRNAs (hsa-miR-191-5p, hsa-miR-151a-3p, hsa-miR-139-5p, hsa-miR-181a-5p, hsa-miR-432-5p, hsa-miR-181b-5p, hsa-miR-195-5p, hsa-miR-328-3p, hsa-miR-106a-5p, and hsa-miR-484) were significantly differentially expressed (false discovery rate <0.05). All of them were up-regulated in patients with autism compared with controls. The targets of these miRNAs were enriched for genes and pathways related to neurodevelopment, brain functions and autism. These findings suggested the participation of these 10 miRNAs in the pathogenesis of autism in the Han Chinese population. Frontiers Media S.A. 2022-03-07 /pmc/articles/PMC8942769/ /pubmed/35342389 http://dx.doi.org/10.3389/fgene.2022.865881 Text en Copyright © 2022 Wang, Lu, Li, Jiang, Jia, Liu, Zhang, Li and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Wang, Ziqi
Lu, Tianlan
Li, Xianjing
Jiang, Miaomiao
Jia, Meixiang
Liu, Jing
Zhang, Dai
Li, Jun
Wang, Lifang
Altered Expression of Brain-specific Autism-Associated miRNAs in the Han Chinese Population
title Altered Expression of Brain-specific Autism-Associated miRNAs in the Han Chinese Population
title_full Altered Expression of Brain-specific Autism-Associated miRNAs in the Han Chinese Population
title_fullStr Altered Expression of Brain-specific Autism-Associated miRNAs in the Han Chinese Population
title_full_unstemmed Altered Expression of Brain-specific Autism-Associated miRNAs in the Han Chinese Population
title_short Altered Expression of Brain-specific Autism-Associated miRNAs in the Han Chinese Population
title_sort altered expression of brain-specific autism-associated mirnas in the han chinese population
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942769/
https://www.ncbi.nlm.nih.gov/pubmed/35342389
http://dx.doi.org/10.3389/fgene.2022.865881
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