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COVID-19-associated Cryptococcus infection (CACI): a review of literature and clinical pearls

BACKGROUND: Cryptococcal infection has been increasingly reported in patients with COVID-19 infection, but the epidemiological factors, presentation, diagnostic certainty, and outcome have not been well-described. METHODS: We reviewed the published cases of COVID-19-associated Cryptococcus infection...

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Autores principales: Regalla, Dinesh, VanNatta, Mollie, Alam, Mohammad, Malek, Alexandre E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942802/
https://www.ncbi.nlm.nih.gov/pubmed/35322336
http://dx.doi.org/10.1007/s15010-022-01805-y
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author Regalla, Dinesh
VanNatta, Mollie
Alam, Mohammad
Malek, Alexandre E.
author_facet Regalla, Dinesh
VanNatta, Mollie
Alam, Mohammad
Malek, Alexandre E.
author_sort Regalla, Dinesh
collection PubMed
description BACKGROUND: Cryptococcal infection has been increasingly reported in patients with COVID-19 infection, but the epidemiological factors, presentation, diagnostic certainty, and outcome have not been well-described. METHODS: We reviewed the published cases of COVID-19-associated Cryptococcus infections (CACI) to shed the light on the burden of this infection. RESULTS: We identified 13 patients with confirmed cryptococcal infection. Cryptococcus infection was primarily seen in patients with severe COVID-19 disease who received corticosteroids therapy and admitted to the intensive care unit. Pulmonary CACI was the most common reported infection followed by cryptococcal meningitis. CONCLUSION: In light of the high mortality rate, clinicians should maintain a high clinical suspicion of CACI in critically ill patients.
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spelling pubmed-89428022022-03-24 COVID-19-associated Cryptococcus infection (CACI): a review of literature and clinical pearls Regalla, Dinesh VanNatta, Mollie Alam, Mohammad Malek, Alexandre E. Infection Brief Report BACKGROUND: Cryptococcal infection has been increasingly reported in patients with COVID-19 infection, but the epidemiological factors, presentation, diagnostic certainty, and outcome have not been well-described. METHODS: We reviewed the published cases of COVID-19-associated Cryptococcus infections (CACI) to shed the light on the burden of this infection. RESULTS: We identified 13 patients with confirmed cryptococcal infection. Cryptococcus infection was primarily seen in patients with severe COVID-19 disease who received corticosteroids therapy and admitted to the intensive care unit. Pulmonary CACI was the most common reported infection followed by cryptococcal meningitis. CONCLUSION: In light of the high mortality rate, clinicians should maintain a high clinical suspicion of CACI in critically ill patients. Springer Berlin Heidelberg 2022-03-24 2022 /pmc/articles/PMC8942802/ /pubmed/35322336 http://dx.doi.org/10.1007/s15010-022-01805-y Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Brief Report
Regalla, Dinesh
VanNatta, Mollie
Alam, Mohammad
Malek, Alexandre E.
COVID-19-associated Cryptococcus infection (CACI): a review of literature and clinical pearls
title COVID-19-associated Cryptococcus infection (CACI): a review of literature and clinical pearls
title_full COVID-19-associated Cryptococcus infection (CACI): a review of literature and clinical pearls
title_fullStr COVID-19-associated Cryptococcus infection (CACI): a review of literature and clinical pearls
title_full_unstemmed COVID-19-associated Cryptococcus infection (CACI): a review of literature and clinical pearls
title_short COVID-19-associated Cryptococcus infection (CACI): a review of literature and clinical pearls
title_sort covid-19-associated cryptococcus infection (caci): a review of literature and clinical pearls
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942802/
https://www.ncbi.nlm.nih.gov/pubmed/35322336
http://dx.doi.org/10.1007/s15010-022-01805-y
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