Full-length MAVS, a mitochondrial antiviral-signaling protein, inhibits hepatitis E virus replication, requiring JAK-STAT signaling

Hepatitis E virus (HEV) infection is the leading cause of acute hepatitis worldwide. The mitochondrial antiviral signaling protein (MAVS)-mediated interferon (IFN) response plays a pivotal role in hepatic antiviral immunity. However, little is known about the effect of overexpression of MAVS on HEV...

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Autores principales: Qu, Changbo, Li, Yang, Li, Yunlong, Pan, Yihang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942808/
https://www.ncbi.nlm.nih.gov/pubmed/35322318
http://dx.doi.org/10.1007/s00705-022-05415-9
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author Qu, Changbo
Li, Yang
Li, Yunlong
Pan, Yihang
author_facet Qu, Changbo
Li, Yang
Li, Yunlong
Pan, Yihang
author_sort Qu, Changbo
collection PubMed
description Hepatitis E virus (HEV) infection is the leading cause of acute hepatitis worldwide. The mitochondrial antiviral signaling protein (MAVS)-mediated interferon (IFN) response plays a pivotal role in hepatic antiviral immunity. However, little is known about the effect of overexpression of MAVS on HEV infection. Full-length MAVS (FL-MAVS) is the main form of MAVS that increases the production of IFNs. Here, we studied the effect of FL-MAVS on HEV infection. We found that overexpression of FL-MAVS profoundly inhibited HEV replication. Furthermore, we showed that the anti-HEV effect of FL-MAVS is largely dependent on JAK-STAT signaling activation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00705-022-05415-9.
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spelling pubmed-89428082022-03-24 Full-length MAVS, a mitochondrial antiviral-signaling protein, inhibits hepatitis E virus replication, requiring JAK-STAT signaling Qu, Changbo Li, Yang Li, Yunlong Pan, Yihang Arch Virol Brief Report Hepatitis E virus (HEV) infection is the leading cause of acute hepatitis worldwide. The mitochondrial antiviral signaling protein (MAVS)-mediated interferon (IFN) response plays a pivotal role in hepatic antiviral immunity. However, little is known about the effect of overexpression of MAVS on HEV infection. Full-length MAVS (FL-MAVS) is the main form of MAVS that increases the production of IFNs. Here, we studied the effect of FL-MAVS on HEV infection. We found that overexpression of FL-MAVS profoundly inhibited HEV replication. Furthermore, we showed that the anti-HEV effect of FL-MAVS is largely dependent on JAK-STAT signaling activation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00705-022-05415-9. Springer Vienna 2022-03-24 2022 /pmc/articles/PMC8942808/ /pubmed/35322318 http://dx.doi.org/10.1007/s00705-022-05415-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Report
Qu, Changbo
Li, Yang
Li, Yunlong
Pan, Yihang
Full-length MAVS, a mitochondrial antiviral-signaling protein, inhibits hepatitis E virus replication, requiring JAK-STAT signaling
title Full-length MAVS, a mitochondrial antiviral-signaling protein, inhibits hepatitis E virus replication, requiring JAK-STAT signaling
title_full Full-length MAVS, a mitochondrial antiviral-signaling protein, inhibits hepatitis E virus replication, requiring JAK-STAT signaling
title_fullStr Full-length MAVS, a mitochondrial antiviral-signaling protein, inhibits hepatitis E virus replication, requiring JAK-STAT signaling
title_full_unstemmed Full-length MAVS, a mitochondrial antiviral-signaling protein, inhibits hepatitis E virus replication, requiring JAK-STAT signaling
title_short Full-length MAVS, a mitochondrial antiviral-signaling protein, inhibits hepatitis E virus replication, requiring JAK-STAT signaling
title_sort full-length mavs, a mitochondrial antiviral-signaling protein, inhibits hepatitis e virus replication, requiring jak-stat signaling
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942808/
https://www.ncbi.nlm.nih.gov/pubmed/35322318
http://dx.doi.org/10.1007/s00705-022-05415-9
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