Hsp90 S-nitrosylation at Cys521, as a conformational switch, modulates cycling of Hsp90-AHA1-CDC37 chaperone machine to aggravate atherosclerosis

Endothelial dysfunction is the initial process of atherosclerosis. Heat shock protein 90 (Hsp90), as a molecular chaperone, plays a crucial role in various cardiovascular diseases. Hsp90 function is regulated by S-nitrosylation (SNO). However, the precise role of SNO-Hsp90 in endothelial dysfunction...

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Detalles Bibliográficos
Autores principales: Zhao, Shuang, Tang, Xin, Miao, Zian, Chen, Yurong, Cao, Jiawei, Song, Tianyu, You, Daiting, Zhong, Yanqing, Lin, Zhe, Wang, Dan, Shi, Zhiguang, Tang, Xinlong, Wang, Dongjin, Chen, Shaoliang, Wang, Liansheng, Gu, Aihua, Chen, Feng, Xie, Liping, Huang, Zhengrong, Wang, Hong, Ji, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942817/
https://www.ncbi.nlm.nih.gov/pubmed/35334246
http://dx.doi.org/10.1016/j.redox.2022.102290

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