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Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer’s disease

Ubiquitin-modified tau aggregates are abundantly found in human brains diagnosed with Alzheimer’s disease (AD) and other tauopathies. Soluble tau oligomers (TauO) are the most neurotoxic tau species that propagate pathology and elicit cognitive deficits, but whether ubiquitination contributes to tau...

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Detalles Bibliográficos
Autores principales:	Puangmalai, Nicha, Sengupta, Urmi, Bhatt, Nemil, Gaikwad, Sagar, Montalbano, Mauro, Bhuyan, Arijit, Garcia, Stephanie, McAllen, Salome, Sonawane, Minal, Jerez, Cynthia, Zhao, Yingxin, Kayed, Rakez
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942844/ https://www.ncbi.nlm.nih.gov/pubmed/35202653 http://dx.doi.org/10.1016/j.jbc.2022.101766

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