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SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
The recent emergence of B.1.1.529, the Omicron variant(1,2), has raised concerns of escape from protection by vaccines and therapeutic antibodies. A key test for potential countermeasures against B.1.1.529 is their activity in preclinical rodent models of respiratory tract disease. Here, using the c...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942849/ https://www.ncbi.nlm.nih.gov/pubmed/35062015 http://dx.doi.org/10.1038/s41586-022-04441-6 |
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author | Halfmann, Peter J. Iida, Shun Iwatsuki-Horimoto, Kiyoko Maemura, Tadashi Kiso, Maki Scheaffer, Suzanne M. Darling, Tamarand L. Joshi, Astha Loeber, Samantha Singh, Gagandeep Foster, Stephanie L. Ying, Baoling Case, James Brett Chong, Zhenlu Whitener, Bradley Moliva, Juan Floyd, Katharine Ujie, Michiko Nakajima, Noriko Ito, Mutsumi Wright, Ryan Uraki, Ryuta Warang, Prajakta Gagne, Matthew Li, Rong Sakai-Tagawa, Yuko Liu, Yanan Larson, Deanna Osorio, Jorge E. Hernandez-Ortiz, Juan P. Henry, Amy R. Ciuoderis, Karl Florek, Kelsey R. Patel, Mit Odle, Abby Wong, Lok-Yin Roy Bateman, Allen C. Wang, Zhongde Edara, Venkata-Viswanadh Chong, Zhenlu Franks, John Jeevan, Trushar Fabrizio, Thomas DeBeauchamp, Jennifer Kercher, Lisa Seiler, Patrick Gonzalez-Reiche, Ana Silvia Sordillo, Emilia Mia Chang, Lauren A. van Bakel, Harm Simon, Viviana Douek, Daniel C. Sullivan, Nancy J. Thackray, Larissa B. Ueki, Hiroshi Yamayoshi, Seiya Imai, Masaki Perlman, Stanley Webby, Richard J. Seder, Robert A. Suthar, Mehul S. García-Sastre, Adolfo Schotsaert, Michael Suzuki, Tadaki Boon, Adrianus C. M. Diamond, Michael S. Kawaoka, Yoshihiro |
author_facet | Halfmann, Peter J. Iida, Shun Iwatsuki-Horimoto, Kiyoko Maemura, Tadashi Kiso, Maki Scheaffer, Suzanne M. Darling, Tamarand L. Joshi, Astha Loeber, Samantha Singh, Gagandeep Foster, Stephanie L. Ying, Baoling Case, James Brett Chong, Zhenlu Whitener, Bradley Moliva, Juan Floyd, Katharine Ujie, Michiko Nakajima, Noriko Ito, Mutsumi Wright, Ryan Uraki, Ryuta Warang, Prajakta Gagne, Matthew Li, Rong Sakai-Tagawa, Yuko Liu, Yanan Larson, Deanna Osorio, Jorge E. Hernandez-Ortiz, Juan P. Henry, Amy R. Ciuoderis, Karl Florek, Kelsey R. Patel, Mit Odle, Abby Wong, Lok-Yin Roy Bateman, Allen C. Wang, Zhongde Edara, Venkata-Viswanadh Chong, Zhenlu Franks, John Jeevan, Trushar Fabrizio, Thomas DeBeauchamp, Jennifer Kercher, Lisa Seiler, Patrick Gonzalez-Reiche, Ana Silvia Sordillo, Emilia Mia Chang, Lauren A. van Bakel, Harm Simon, Viviana Douek, Daniel C. Sullivan, Nancy J. Thackray, Larissa B. Ueki, Hiroshi Yamayoshi, Seiya Imai, Masaki Perlman, Stanley Webby, Richard J. Seder, Robert A. Suthar, Mehul S. García-Sastre, Adolfo Schotsaert, Michael Suzuki, Tadaki Boon, Adrianus C. M. Diamond, Michael S. Kawaoka, Yoshihiro |
author_sort | Halfmann, Peter J. |
collection | PubMed |
description | The recent emergence of B.1.1.529, the Omicron variant(1,2), has raised concerns of escape from protection by vaccines and therapeutic antibodies. A key test for potential countermeasures against B.1.1.529 is their activity in preclinical rodent models of respiratory tract disease. Here, using the collaborative network of the SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme of the National Institute of Allergy and Infectious Diseases (NIAID), we evaluated the ability of several B.1.1.529 isolates to cause infection and disease in immunocompetent and human ACE2 (hACE2)-expressing mice and hamsters. Despite modelling data indicating that B.1.1.529 spike can bind more avidly to mouse ACE2 (refs. (3,4)), we observed less infection by B.1.1.529 in 129, C57BL/6, BALB/c and K18-hACE2 transgenic mice than by previous SARS-CoV-2 variants, with limited weight loss and lower viral burden in the upper and lower respiratory tracts. In wild-type and hACE2 transgenic hamsters, lung infection, clinical disease and pathology with B.1.1.529 were also milder than with historical isolates or other SARS-CoV-2 variants of concern. Overall, experiments from the SAVE/NIAID network with several B.1.1.529 isolates demonstrate attenuated lung disease in rodents, which parallels preliminary human clinical data. |
format | Online Article Text |
id | pubmed-8942849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-89428492022-04-07 SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters Halfmann, Peter J. Iida, Shun Iwatsuki-Horimoto, Kiyoko Maemura, Tadashi Kiso, Maki Scheaffer, Suzanne M. Darling, Tamarand L. Joshi, Astha Loeber, Samantha Singh, Gagandeep Foster, Stephanie L. Ying, Baoling Case, James Brett Chong, Zhenlu Whitener, Bradley Moliva, Juan Floyd, Katharine Ujie, Michiko Nakajima, Noriko Ito, Mutsumi Wright, Ryan Uraki, Ryuta Warang, Prajakta Gagne, Matthew Li, Rong Sakai-Tagawa, Yuko Liu, Yanan Larson, Deanna Osorio, Jorge E. Hernandez-Ortiz, Juan P. Henry, Amy R. Ciuoderis, Karl Florek, Kelsey R. Patel, Mit Odle, Abby Wong, Lok-Yin Roy Bateman, Allen C. Wang, Zhongde Edara, Venkata-Viswanadh Chong, Zhenlu Franks, John Jeevan, Trushar Fabrizio, Thomas DeBeauchamp, Jennifer Kercher, Lisa Seiler, Patrick Gonzalez-Reiche, Ana Silvia Sordillo, Emilia Mia Chang, Lauren A. van Bakel, Harm Simon, Viviana Douek, Daniel C. Sullivan, Nancy J. Thackray, Larissa B. Ueki, Hiroshi Yamayoshi, Seiya Imai, Masaki Perlman, Stanley Webby, Richard J. Seder, Robert A. Suthar, Mehul S. García-Sastre, Adolfo Schotsaert, Michael Suzuki, Tadaki Boon, Adrianus C. M. Diamond, Michael S. Kawaoka, Yoshihiro Nature Article The recent emergence of B.1.1.529, the Omicron variant(1,2), has raised concerns of escape from protection by vaccines and therapeutic antibodies. A key test for potential countermeasures against B.1.1.529 is their activity in preclinical rodent models of respiratory tract disease. Here, using the collaborative network of the SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme of the National Institute of Allergy and Infectious Diseases (NIAID), we evaluated the ability of several B.1.1.529 isolates to cause infection and disease in immunocompetent and human ACE2 (hACE2)-expressing mice and hamsters. Despite modelling data indicating that B.1.1.529 spike can bind more avidly to mouse ACE2 (refs. (3,4)), we observed less infection by B.1.1.529 in 129, C57BL/6, BALB/c and K18-hACE2 transgenic mice than by previous SARS-CoV-2 variants, with limited weight loss and lower viral burden in the upper and lower respiratory tracts. In wild-type and hACE2 transgenic hamsters, lung infection, clinical disease and pathology with B.1.1.529 were also milder than with historical isolates or other SARS-CoV-2 variants of concern. Overall, experiments from the SAVE/NIAID network with several B.1.1.529 isolates demonstrate attenuated lung disease in rodents, which parallels preliminary human clinical data. Nature Publishing Group UK 2022-01-21 2022 /pmc/articles/PMC8942849/ /pubmed/35062015 http://dx.doi.org/10.1038/s41586-022-04441-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Halfmann, Peter J. Iida, Shun Iwatsuki-Horimoto, Kiyoko Maemura, Tadashi Kiso, Maki Scheaffer, Suzanne M. Darling, Tamarand L. Joshi, Astha Loeber, Samantha Singh, Gagandeep Foster, Stephanie L. Ying, Baoling Case, James Brett Chong, Zhenlu Whitener, Bradley Moliva, Juan Floyd, Katharine Ujie, Michiko Nakajima, Noriko Ito, Mutsumi Wright, Ryan Uraki, Ryuta Warang, Prajakta Gagne, Matthew Li, Rong Sakai-Tagawa, Yuko Liu, Yanan Larson, Deanna Osorio, Jorge E. Hernandez-Ortiz, Juan P. Henry, Amy R. Ciuoderis, Karl Florek, Kelsey R. Patel, Mit Odle, Abby Wong, Lok-Yin Roy Bateman, Allen C. Wang, Zhongde Edara, Venkata-Viswanadh Chong, Zhenlu Franks, John Jeevan, Trushar Fabrizio, Thomas DeBeauchamp, Jennifer Kercher, Lisa Seiler, Patrick Gonzalez-Reiche, Ana Silvia Sordillo, Emilia Mia Chang, Lauren A. van Bakel, Harm Simon, Viviana Douek, Daniel C. Sullivan, Nancy J. Thackray, Larissa B. Ueki, Hiroshi Yamayoshi, Seiya Imai, Masaki Perlman, Stanley Webby, Richard J. Seder, Robert A. Suthar, Mehul S. García-Sastre, Adolfo Schotsaert, Michael Suzuki, Tadaki Boon, Adrianus C. M. Diamond, Michael S. Kawaoka, Yoshihiro SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters |
title | SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters |
title_full | SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters |
title_fullStr | SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters |
title_full_unstemmed | SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters |
title_short | SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters |
title_sort | sars-cov-2 omicron virus causes attenuated disease in mice and hamsters |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942849/ https://www.ncbi.nlm.nih.gov/pubmed/35062015 http://dx.doi.org/10.1038/s41586-022-04441-6 |
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