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SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

The recent emergence of B.1.1.529, the Omicron variant(1,2), has raised concerns of escape from protection by vaccines and therapeutic antibodies. A key test for potential countermeasures against B.1.1.529 is their activity in preclinical rodent models of respiratory tract disease. Here, using the c...

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Autores principales: Halfmann, Peter J., Iida, Shun, Iwatsuki-Horimoto, Kiyoko, Maemura, Tadashi, Kiso, Maki, Scheaffer, Suzanne M., Darling, Tamarand L., Joshi, Astha, Loeber, Samantha, Singh, Gagandeep, Foster, Stephanie L., Ying, Baoling, Case, James Brett, Chong, Zhenlu, Whitener, Bradley, Moliva, Juan, Floyd, Katharine, Ujie, Michiko, Nakajima, Noriko, Ito, Mutsumi, Wright, Ryan, Uraki, Ryuta, Warang, Prajakta, Gagne, Matthew, Li, Rong, Sakai-Tagawa, Yuko, Liu, Yanan, Larson, Deanna, Osorio, Jorge E., Hernandez-Ortiz, Juan P., Henry, Amy R., Ciuoderis, Karl, Florek, Kelsey R., Patel, Mit, Odle, Abby, Wong, Lok-Yin Roy, Bateman, Allen C., Wang, Zhongde, Edara, Venkata-Viswanadh, Franks, John, Jeevan, Trushar, Fabrizio, Thomas, DeBeauchamp, Jennifer, Kercher, Lisa, Seiler, Patrick, Gonzalez-Reiche, Ana Silvia, Sordillo, Emilia Mia, Chang, Lauren A., van Bakel, Harm, Simon, Viviana, Douek, Daniel C., Sullivan, Nancy J., Thackray, Larissa B., Ueki, Hiroshi, Yamayoshi, Seiya, Imai, Masaki, Perlman, Stanley, Webby, Richard J., Seder, Robert A., Suthar, Mehul S., García-Sastre, Adolfo, Schotsaert, Michael, Suzuki, Tadaki, Boon, Adrianus C. M., Diamond, Michael S., Kawaoka, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942849/
https://www.ncbi.nlm.nih.gov/pubmed/35062015
http://dx.doi.org/10.1038/s41586-022-04441-6
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author Halfmann, Peter J.
Iida, Shun
Iwatsuki-Horimoto, Kiyoko
Maemura, Tadashi
Kiso, Maki
Scheaffer, Suzanne M.
Darling, Tamarand L.
Joshi, Astha
Loeber, Samantha
Singh, Gagandeep
Foster, Stephanie L.
Ying, Baoling
Case, James Brett
Chong, Zhenlu
Whitener, Bradley
Moliva, Juan
Floyd, Katharine
Ujie, Michiko
Nakajima, Noriko
Ito, Mutsumi
Wright, Ryan
Uraki, Ryuta
Warang, Prajakta
Gagne, Matthew
Li, Rong
Sakai-Tagawa, Yuko
Liu, Yanan
Larson, Deanna
Osorio, Jorge E.
Hernandez-Ortiz, Juan P.
Henry, Amy R.
Ciuoderis, Karl
Florek, Kelsey R.
Patel, Mit
Odle, Abby
Wong, Lok-Yin Roy
Bateman, Allen C.
Wang, Zhongde
Edara, Venkata-Viswanadh
Chong, Zhenlu
Franks, John
Jeevan, Trushar
Fabrizio, Thomas
DeBeauchamp, Jennifer
Kercher, Lisa
Seiler, Patrick
Gonzalez-Reiche, Ana Silvia
Sordillo, Emilia Mia
Chang, Lauren A.
van Bakel, Harm
Simon, Viviana
Douek, Daniel C.
Sullivan, Nancy J.
Thackray, Larissa B.
Ueki, Hiroshi
Yamayoshi, Seiya
Imai, Masaki
Perlman, Stanley
Webby, Richard J.
Seder, Robert A.
Suthar, Mehul S.
García-Sastre, Adolfo
Schotsaert, Michael
Suzuki, Tadaki
Boon, Adrianus C. M.
Diamond, Michael S.
Kawaoka, Yoshihiro
author_facet Halfmann, Peter J.
Iida, Shun
Iwatsuki-Horimoto, Kiyoko
Maemura, Tadashi
Kiso, Maki
Scheaffer, Suzanne M.
Darling, Tamarand L.
Joshi, Astha
Loeber, Samantha
Singh, Gagandeep
Foster, Stephanie L.
Ying, Baoling
Case, James Brett
Chong, Zhenlu
Whitener, Bradley
Moliva, Juan
Floyd, Katharine
Ujie, Michiko
Nakajima, Noriko
Ito, Mutsumi
Wright, Ryan
Uraki, Ryuta
Warang, Prajakta
Gagne, Matthew
Li, Rong
Sakai-Tagawa, Yuko
Liu, Yanan
Larson, Deanna
Osorio, Jorge E.
Hernandez-Ortiz, Juan P.
Henry, Amy R.
Ciuoderis, Karl
Florek, Kelsey R.
Patel, Mit
Odle, Abby
Wong, Lok-Yin Roy
Bateman, Allen C.
Wang, Zhongde
Edara, Venkata-Viswanadh
Chong, Zhenlu
Franks, John
Jeevan, Trushar
Fabrizio, Thomas
DeBeauchamp, Jennifer
Kercher, Lisa
Seiler, Patrick
Gonzalez-Reiche, Ana Silvia
Sordillo, Emilia Mia
Chang, Lauren A.
van Bakel, Harm
Simon, Viviana
Douek, Daniel C.
Sullivan, Nancy J.
Thackray, Larissa B.
Ueki, Hiroshi
Yamayoshi, Seiya
Imai, Masaki
Perlman, Stanley
Webby, Richard J.
Seder, Robert A.
Suthar, Mehul S.
García-Sastre, Adolfo
Schotsaert, Michael
Suzuki, Tadaki
Boon, Adrianus C. M.
Diamond, Michael S.
Kawaoka, Yoshihiro
author_sort Halfmann, Peter J.
collection PubMed
description The recent emergence of B.1.1.529, the Omicron variant(1,2), has raised concerns of escape from protection by vaccines and therapeutic antibodies. A key test for potential countermeasures against B.1.1.529 is their activity in preclinical rodent models of respiratory tract disease. Here, using the collaborative network of the SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme of the National Institute of Allergy and Infectious Diseases (NIAID), we evaluated the ability of several B.1.1.529 isolates to cause infection and disease in immunocompetent and human ACE2 (hACE2)-expressing mice and hamsters. Despite modelling data indicating that B.1.1.529 spike can bind more avidly to mouse ACE2 (refs. (3,4)), we observed less infection by B.1.1.529 in 129, C57BL/6, BALB/c and K18-hACE2 transgenic mice than by previous SARS-CoV-2 variants, with limited weight loss and lower viral burden in the upper and lower respiratory tracts. In wild-type and hACE2 transgenic hamsters, lung infection, clinical disease and pathology with B.1.1.529 were also milder than with historical isolates or other SARS-CoV-2 variants of concern. Overall, experiments from the SAVE/NIAID network with several B.1.1.529 isolates demonstrate attenuated lung disease in rodents, which parallels preliminary human clinical data.
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spelling pubmed-89428492022-04-07 SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters Halfmann, Peter J. Iida, Shun Iwatsuki-Horimoto, Kiyoko Maemura, Tadashi Kiso, Maki Scheaffer, Suzanne M. Darling, Tamarand L. Joshi, Astha Loeber, Samantha Singh, Gagandeep Foster, Stephanie L. Ying, Baoling Case, James Brett Chong, Zhenlu Whitener, Bradley Moliva, Juan Floyd, Katharine Ujie, Michiko Nakajima, Noriko Ito, Mutsumi Wright, Ryan Uraki, Ryuta Warang, Prajakta Gagne, Matthew Li, Rong Sakai-Tagawa, Yuko Liu, Yanan Larson, Deanna Osorio, Jorge E. Hernandez-Ortiz, Juan P. Henry, Amy R. Ciuoderis, Karl Florek, Kelsey R. Patel, Mit Odle, Abby Wong, Lok-Yin Roy Bateman, Allen C. Wang, Zhongde Edara, Venkata-Viswanadh Chong, Zhenlu Franks, John Jeevan, Trushar Fabrizio, Thomas DeBeauchamp, Jennifer Kercher, Lisa Seiler, Patrick Gonzalez-Reiche, Ana Silvia Sordillo, Emilia Mia Chang, Lauren A. van Bakel, Harm Simon, Viviana Douek, Daniel C. Sullivan, Nancy J. Thackray, Larissa B. Ueki, Hiroshi Yamayoshi, Seiya Imai, Masaki Perlman, Stanley Webby, Richard J. Seder, Robert A. Suthar, Mehul S. García-Sastre, Adolfo Schotsaert, Michael Suzuki, Tadaki Boon, Adrianus C. M. Diamond, Michael S. Kawaoka, Yoshihiro Nature Article The recent emergence of B.1.1.529, the Omicron variant(1,2), has raised concerns of escape from protection by vaccines and therapeutic antibodies. A key test for potential countermeasures against B.1.1.529 is their activity in preclinical rodent models of respiratory tract disease. Here, using the collaborative network of the SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme of the National Institute of Allergy and Infectious Diseases (NIAID), we evaluated the ability of several B.1.1.529 isolates to cause infection and disease in immunocompetent and human ACE2 (hACE2)-expressing mice and hamsters. Despite modelling data indicating that B.1.1.529 spike can bind more avidly to mouse ACE2 (refs. (3,4)), we observed less infection by B.1.1.529 in 129, C57BL/6, BALB/c and K18-hACE2 transgenic mice than by previous SARS-CoV-2 variants, with limited weight loss and lower viral burden in the upper and lower respiratory tracts. In wild-type and hACE2 transgenic hamsters, lung infection, clinical disease and pathology with B.1.1.529 were also milder than with historical isolates or other SARS-CoV-2 variants of concern. Overall, experiments from the SAVE/NIAID network with several B.1.1.529 isolates demonstrate attenuated lung disease in rodents, which parallels preliminary human clinical data. Nature Publishing Group UK 2022-01-21 2022 /pmc/articles/PMC8942849/ /pubmed/35062015 http://dx.doi.org/10.1038/s41586-022-04441-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Halfmann, Peter J.
Iida, Shun
Iwatsuki-Horimoto, Kiyoko
Maemura, Tadashi
Kiso, Maki
Scheaffer, Suzanne M.
Darling, Tamarand L.
Joshi, Astha
Loeber, Samantha
Singh, Gagandeep
Foster, Stephanie L.
Ying, Baoling
Case, James Brett
Chong, Zhenlu
Whitener, Bradley
Moliva, Juan
Floyd, Katharine
Ujie, Michiko
Nakajima, Noriko
Ito, Mutsumi
Wright, Ryan
Uraki, Ryuta
Warang, Prajakta
Gagne, Matthew
Li, Rong
Sakai-Tagawa, Yuko
Liu, Yanan
Larson, Deanna
Osorio, Jorge E.
Hernandez-Ortiz, Juan P.
Henry, Amy R.
Ciuoderis, Karl
Florek, Kelsey R.
Patel, Mit
Odle, Abby
Wong, Lok-Yin Roy
Bateman, Allen C.
Wang, Zhongde
Edara, Venkata-Viswanadh
Chong, Zhenlu
Franks, John
Jeevan, Trushar
Fabrizio, Thomas
DeBeauchamp, Jennifer
Kercher, Lisa
Seiler, Patrick
Gonzalez-Reiche, Ana Silvia
Sordillo, Emilia Mia
Chang, Lauren A.
van Bakel, Harm
Simon, Viviana
Douek, Daniel C.
Sullivan, Nancy J.
Thackray, Larissa B.
Ueki, Hiroshi
Yamayoshi, Seiya
Imai, Masaki
Perlman, Stanley
Webby, Richard J.
Seder, Robert A.
Suthar, Mehul S.
García-Sastre, Adolfo
Schotsaert, Michael
Suzuki, Tadaki
Boon, Adrianus C. M.
Diamond, Michael S.
Kawaoka, Yoshihiro
SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
title SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
title_full SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
title_fullStr SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
title_full_unstemmed SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
title_short SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
title_sort sars-cov-2 omicron virus causes attenuated disease in mice and hamsters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942849/
https://www.ncbi.nlm.nih.gov/pubmed/35062015
http://dx.doi.org/10.1038/s41586-022-04441-6
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