Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

Activated T cells secrete interferon-γ, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme(1–4). Here we show that despite tryptophan depletion, in-frame protein synthesis continues across tryptophan codons. We identified tryptophan-to-ph...

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Detalles Bibliográficos
Autores principales: Pataskar, Abhijeet, Champagne, Julien, Nagel, Remco, Kenski, Juliana, Laos, Maarja, Michaux, Justine, Pak, Hui Song, Bleijerveld, Onno B., Mordente, Kelly, Navarro, Jasmine Montenegro, Blommaert, Naomi, Nielsen, Morten M., Lovecchio, Domenica, Stone, Everett, Georgiou, George, de Gooijer, Mark C., van Tellingen, Olaf, Altelaar, Maarten, Joosten, Robbie P., Perrakis, Anastassis, Olweus, Johanna, Bassani-Sternberg, Michal, Peeper, Daniel S., Agami, Reuven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942854/
https://www.ncbi.nlm.nih.gov/pubmed/35264796
http://dx.doi.org/10.1038/s41586-022-04499-2

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