Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases

Exosomes are extracellular vesicles with the diameter ranging from 50 to 100 nm and are found in different body fluids such as blood, cerebrospinal fluid (CSF), urine and saliva. Like in case of various diseases, based on the parent cells, the content of exosomes (protein, mRNA, miRNA, DNA, lipids a...

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Autores principales: Shetgaonkar, Gayatri Gopal, Marques, Shirleen Miriam, DCruz, Cleona E. M., Vibhavari, R. J. A., Kumar, Lalit, Shirodkar, Rupesh Kalidas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942947/
https://www.ncbi.nlm.nih.gov/pubmed/34365576
http://dx.doi.org/10.1007/s13346-021-01026-0
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author Shetgaonkar, Gayatri Gopal
Marques, Shirleen Miriam
DCruz, Cleona E. M.
Vibhavari, R. J. A.
Kumar, Lalit
Shirodkar, Rupesh Kalidas
author_facet Shetgaonkar, Gayatri Gopal
Marques, Shirleen Miriam
DCruz, Cleona E. M.
Vibhavari, R. J. A.
Kumar, Lalit
Shirodkar, Rupesh Kalidas
author_sort Shetgaonkar, Gayatri Gopal
collection PubMed
description Exosomes are extracellular vesicles with the diameter ranging from 50 to 100 nm and are found in different body fluids such as blood, cerebrospinal fluid (CSF), urine and saliva. Like in case of various diseases, based on the parent cells, the content of exosomes (protein, mRNA, miRNA, DNA, lipids and metabolites) varies and thus can be utilized as potential biomarker for diagnosis and prognosis of the brain diseases. Furthermore, utilizing the natural potential exosomes to cross the blood–brain barrier and by specifically decorating it with the ligand as per the desired brain sites therapeutics can be delivered to brain parenchyma. This review article conveys the importance of exosomes and their use in the treatment and diagnosis of brain/central nervous system diseases. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-89429472022-04-07 Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases Shetgaonkar, Gayatri Gopal Marques, Shirleen Miriam DCruz, Cleona E. M. Vibhavari, R. J. A. Kumar, Lalit Shirodkar, Rupesh Kalidas Drug Deliv Transl Res Review Article Exosomes are extracellular vesicles with the diameter ranging from 50 to 100 nm and are found in different body fluids such as blood, cerebrospinal fluid (CSF), urine and saliva. Like in case of various diseases, based on the parent cells, the content of exosomes (protein, mRNA, miRNA, DNA, lipids and metabolites) varies and thus can be utilized as potential biomarker for diagnosis and prognosis of the brain diseases. Furthermore, utilizing the natural potential exosomes to cross the blood–brain barrier and by specifically decorating it with the ligand as per the desired brain sites therapeutics can be delivered to brain parenchyma. This review article conveys the importance of exosomes and their use in the treatment and diagnosis of brain/central nervous system diseases. GRAPHICAL ABSTRACT: [Image: see text] Springer US 2021-08-07 2022 /pmc/articles/PMC8942947/ /pubmed/34365576 http://dx.doi.org/10.1007/s13346-021-01026-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Shetgaonkar, Gayatri Gopal
Marques, Shirleen Miriam
DCruz, Cleona E. M.
Vibhavari, R. J. A.
Kumar, Lalit
Shirodkar, Rupesh Kalidas
Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases
title Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases
title_full Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases
title_fullStr Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases
title_full_unstemmed Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases
title_short Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases
title_sort exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942947/
https://www.ncbi.nlm.nih.gov/pubmed/34365576
http://dx.doi.org/10.1007/s13346-021-01026-0
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